Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT3 | O60678 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27433811 | 0.96 | — | — | |
| Water SCHEMBL5930817 | 0.96 | — | — | |
| Water SCHEMBL2274840 | 0.96 | PRMT3 (0.35) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| Water SCHEMBL28209888 | 0.96 | — | — | |
| Water SCHEMBL2274846 | 0.96 | PRMT3 (0.35) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL15225 | 0.93 | — | — | |
| SCHEMBL6247615 | 0.93 | CARM1 (0.37) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| Alcohol SCHEMBL9413740 | 0.90 | ALDH1A1 (0.40) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL29936682 | 0.89 | — | — | |
| Bromide SCHEMBL437925 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1046423-B1 | Layered noble metal-containing exhaust gas catalyst and its preparation | UMICORE AG & CO KG (DE) | 2007-07-25 | — | — | EP | disclosed |
| EP-1138382-B1 | Single layer high perfomance catalyst | UMICORE AG & CO KG (DE) | 2005-06-15 | — | — | EP | disclosed |
| US-20040028589-A1 | Catalyst for destruction of co, voc, and halogenated organic emissions | OMG AG & CO. KG (DE) | 2004-02-12 | — | — | US | disclosed |
| US-6602820-B1 | Method for producing a nitrogen oxide storage material and a storage material made with it | DEGUSSA-HULS AKTIENGESELLSCHAFT (DE) | 2003-08-05 | — | — | US | disclosed |
| EP-1326701-A1 | CATALYST FOR DESTRUCTION OF CO, VOC, AND HALOGENATED ORGANIC EMISSIONS | Degussa AG (DE) | 2003-07-16 | — | — | EP | disclosed |
| US-6524992-B2 | Two supports; first support of an active alumina, ceria or ceria/zirconia coating; both supports having a coating including platinum and rhodium; used in catalytic exhaust systems | DMC2 DEGUSSA METALS CATALYSTS CERDAC AG (DE) | 2003-02-25 | — | — | US | disclosed |
| WO-2002034371-A1 | CATALYST FOR DESTRUCTION OF CO, VOC, AND HALOGENATED ORGANIC EMISSIONS | DEGUSSA AG (DE) | 2002-05-02 | — | — | WO | disclosed |
| EP-1199096-A1 | Catalyst for destruction of CO, VOC, and halogenated organic emissions | Degussa AG (DE) | 2002-04-24 | — | — | EP | disclosed |
| US-20010046941-A1 | Single layer high performance catalyst | UMICORE AG & CO. KG (DE) | 2001-11-29 | — | — | US | disclosed |
| EP-1138382-A1 | Single layer high perfomance catalyst | dmc2 Degussa Metals Catalysts Cerdec AG (DE) | 2001-10-04 | — | — | EP | disclosed |
| US-6294140-B1 | CATALYST COMPRISING CARRIER BODY, INNER LAYER COMPRISING PLATINUM DEPOSITED ON FIRST SUPPORT AND OXYGEN STORAGE COMPONENT, OUTER LAYER COMPRISING PLATINUM AND RHODIUM DEPOSITED ON SECOND SUPPORT AND OXYGEN STORAGE COMPONENT | DEGUSSA AG (DE) | 2001-09-25 | — | — | US | disclosed |
| EP-1046423-A2 | Layered noble metal-containing exhaust gas catalyst and its preparation | Degussa-Hüls Aktiengesellschaft (DE) | 2000-10-25 | — | — | EP | disclosed |