Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16096838 | 0.81 | NPC1 (0.40) | NPC1RAB9AALDH1A1PNMTMAPT | |
| SCHEMBL27624642 | 0.80 | SLC1A3 (0.45) | NPC1RAB9ASLC1A3SLC1A2SLC1A1 | |
| SCHEMBL648281 | 0.74 | PNMT (0.47) | NPC1RAB9ASLC1A3SLC1A2SLC1A1 | |
| SCHEMBL4462321 | 0.72 | NPC1 (0.41) | NPC1RAB9AALDH1A1PNMTL3MBTL1 | |
| SCHEMBL9948353 | 0.72 | PNMT (0.50) | NPC1RAB9ANOTUMALDH1A1PTGDR2 | |
| SCHEMBL7702275 | 0.71 | HTR7 (0.39) | NPC1RAB9AALDH1A1PNMTMAPT | |
| SCHEMBL28388012 | 0.70 | NPC1 (0.43) | NPC1RAB9AALDH1A1PNMTMAPT | |
| SCHEMBL21758208 | 0.69 | NPC1 (0.47) | NPC1RAB9ASLC1A3SLC1A2SLC1A1 | |
| SCHEMBL21046174 | 0.69 | HTR2B (0.49) | NPC1RAB9ASLC1A3SLC1A2SLC1A1 | |
| SCHEMBL6129732 | 0.68 | PNMT (0.37) | NPC1RAB9APNMTHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070172517-A1 | Compositions capable of facilitation penetration across a biological barrier | CHIASMA, INC. | 2007-07-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070172517-A1 | Compositions capable of facilitation penetration across a biological barrier | PGF, MMP8, FCGR3B | NPC1 129/4885RAB9A 1746/4885NOTUM 3824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.