Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5511905 | 0.93 | ADRB2 (0.42) | KMT2AKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL5116402 | 0.86 | SIGMAR1 (0.45) | KMT2AMAOBSIGMAR1MCHR1BACE1 | |
| SCHEMBL5507598 | 0.84 | OPRD1 (0.46) | OPRM1OPRK1 | |
| SCHEMBL5112877 | 0.79 | PARP1 (0.47) | KMT2AMAOBSIGMAR1MCHR1BACE1 | |
| SCHEMBL5504897 | 0.76 | SLC6A12 (0.47) | KMT2AALDH1A1SIGMAR1OPRM1OPRK1 | |
| SCHEMBL5503754 | 0.72 | OPRM1 (0.45) | ALDH1A1MAPTSIGMAR1OPRM1OPRK1 | |
| SCHEMBL5115820 | 0.71 | SLC6A12 (0.52) | ALDH1A1MAPTSIGMAR1MCHR1OPRM1 | |
| SCHEMBL5117986 | 0.71 | OPRD1 (0.49) | OPRM1OPRK1 | |
| SCHEMBL5126312 | 0.69 | OPRD1 (0.46) | KMT2AMEN1OPRM1OPRK1OPRL1 | |
| SCHEMBL5505687 | 0.68 | OPRM1 (0.45) | KMT2AKDM4EMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | claimed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | claimed |
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |