Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727669 | 0.84 | MTNR1A (0.43) | — | |
| SCHEMBL10405364 | 0.83 | GABRA1 (0.36) | — | |
| SCHEMBL14435039 | 0.82 | AKR1B1 (0.40) | AKR1B1CYP3A4 | |
| SCHEMBL14446493 | 0.79 | CNR2 (0.41) | CYP3A4 | |
| SCHEMBL5506271 | 0.79 | MAOA (0.41) | AKR1B1CYP3A4 | |
| SCHEMBL9727509 | 0.75 | DRD1 (0.43) | AKR1B1CYP3A4 | |
| SCHEMBL5502112 | 0.75 | DRD2 (0.45) | CYP3A4 | |
| SCHEMBL9727677 | 0.73 | PTGDR2 (0.38) | — | |
| SCHEMBL5501181 | 0.72 | HRH3 (0.43) | CYP3A4HRH3 | |
| SCHEMBL9727764 | 0.71 | IGF1R (0.35) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070202547-A1 | Methods For Detecting Substances Which Bind To The Amyloid Precursor Protein Or Beta Amyloid Fragments, And Binding Compounds | MERCK & CO., INC. | 2007-08-30 | — | — | US | disclosed |
| US-20070202547-A1 | Methods For Detecting Substances Which Bind To The Amyloid Precursor Protein Or Beta Amyloid Fragments, And Binding Compounds | MERCK & CO., INC. | 2007-08-30 | — | — | US | disclosed |
| US-20070202547-A1 | Methods For Detecting Substances Which Bind To The Amyloid Precursor Protein Or Beta Amyloid Fragments, And Binding Compounds | MERCK & CO., INC. | 2007-08-30 | — | — | US | disclosed |
| EP-1743170-A2 | METHODS FOR DETECTING SUBSTANCES WHICH BIND TO THE AMYLOID PRECURSOR PROTEIN OR BETA AMYLOID FRAGMENTS, AND BINDING COMPOUNDS | Merck & Co., Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005096730-A2 | METHODS FOR DETECTING SUBSTANCES WHICH BIND TO THE AMYLOID PRECURSOR PROTEIN OR BETA AMYLOID FRAGMENTS, AND BINDING COMPOUNDS | MERCK & CO., INC. (US) | 2005-10-20 | — | — | WO | disclosed |
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |