Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.48 |
| ▸ | IL1RN | P18510 | 1/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5146133 | 0.75 | HTR6 (0.46) | KMT2AALDH1A1MEN1CA1CA2 | |
| SCHEMBL3769126 | 0.74 | PGR (0.73) | KEAP1IL1RNERAP1PGRKMT2A | |
| SCHEMBL691617 | 0.74 | ALDH1A1 (0.35) | KMT2AALDH1A1MEN1 | |
| SCHEMBL7051356 | 0.73 | KEAP1 (0.53) | KEAP1IL1RNERAP1PGRKMT2A | |
| SCHEMBL1828766 | 0.72 | HSD11B1 (0.33) | KMT2AALDH1A1MEN1 | |
| SCHEMBL5510640 | 0.72 | CA1 (0.35) | KMT2AALDH1A1MEN1CA1CA2 | |
| SCHEMBL11484289 | 0.71 | ADRB2 (0.43) | KEAP1IL1RNERAP1 | |
| SCHEMBL10455160 | 0.70 | PGR (0.75) | KEAP1IL1RNERAP1PGRALDH1A1 | |
| SCHEMBL11221736 | 0.70 | PGR (0.59) | KEAP1IL1RNERAP1PGRKMT2A | |
| SCHEMBL11030180 | 0.68 | PGR (0.57) | KEAP1IL1RNERAP1PGRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844011-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006081343-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-03 | — | — | WO | disclosed |