Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 12/20 | 0.44 |
| ▸ | CTSL | P07711 | 10/20 | 0.44 |
| ▸ | CTSK | P43235 | 10/20 | 0.44 |
| ▸ | CTSB | P07858 | 9/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6168799 | 0.90 | CTSL (0.41) | CTSSCTSLCTSKCTSBPRCP | |
| SCHEMBL4700947 | 0.80 | CTSL (0.66) | CTSSCTSLCTSKCTSB | |
| SCHEMBL6001121 | 0.80 | CTSB (0.53) | CTSSCTSLCTSKCTSB | |
| SCHEMBL5512349 | 0.79 | CTSK (0.47) | CTSSCTSLCTSKCTSBPRCP | |
| SCHEMBL5512355 | 0.79 | CTSK (0.47) | CTSSCTSLCTSKCTSBPRCP | |
| SCHEMBL4700791 | 0.77 | CTSS (0.45) | CTSSCTSLCTSKCTSB | |
| SCHEMBL4700794 | 0.76 | CTSS (0.62) | CTSSCTSLCTSKCTSB | |
| SCHEMBL5518599 | 0.75 | PORCN (0.46) | CTSSCTSLCTSKCTSB | |
| SCHEMBL6208701 | 0.73 | CTSS (0.48) | CTSSCTSLCTSKCTSB | |
| SCHEMBL6172215 | 0.72 | CTSK (0.58) | CTSSCTSLCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537074-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC. (CA) | 2005-06-08 | — | — | EP | claimed |
| WO-2004022526-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2004-03-18 | — | — | WO | claimed |
| US-7279478-B2 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA & CO. (CA) | 2007-10-09 | — | — | US | disclosed |