Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | PER2 | O15055 | 1/20 | 0.44 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.44 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 2/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242597 | 0.98 | ESR1 (0.47) | ESR1PER2CRY1CRY2CETP | |
| SCHEMBL17685583 | 0.96 | ESR1 (0.49) | ESR1PER2CRY1CRY2CETP | |
| SCHEMBL9879559 | 0.96 | ESR1 (0.46) | ESR1PER2CRY1CRY2CETP | |
| SCHEMBL5523393 | 0.95 | ESR1 (0.46) | ESR1PER2CRY1CRY2CETP | |
| Water SCHEMBL20853622 | 0.95 | ESR1 (0.46) | ESR1PER2CRY1CRY2CETP | |
| SCHEMBL2847553 | 0.94 | PER2 (0.46) | ESR1PER2CRY1CRY2CETP | |
| SCHEMBL30096475 | 0.88 | ESR1 (0.48) | ESR1PER2CRY1CRY2CETP | |
| SCHEMBL9879557 | 0.88 | ESR1 (0.48) | ESR1PER2CRY1CRY2CETP | |
| SCHEMBL5526598 | 0.88 | MAPT (0.34) | ESR1PER2CRY1CRY2LMNA | |
| Water SCHEMBL31143099 | 0.87 | ESR1 (0.47) | ESR1PER2CRY1CRY2CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101948906-B | Reagent with protease reaction promoter and/or pigment stabilizing agent | ASAHI KASEI PHARMA CORP | 2013-02-27 | — | — | CN | disclosed |
| CN-101948906-A | The reagent that contains protease reaction promoter and/or colorant stabilizer | ASAHI KASEI PHARMA CORP | 2011-01-19 | — | — | CN | disclosed |
| CN-101023168-B | Reagent containing protease reaction promoter and/or pigment stabilizer | ASAHI KASEI PHARMA CORP | 2010-10-13 | — | — | CN | disclosed |
| US-20070224685-A1 | Reagent Containing Protease Reaction Promoter and/or Colorant Stabilizer | ASAHI KASEI PHARMA CORPORATION (JP) | 2007-09-27 | — | — | US | disclosed |
| CN-101023168-A | Reagent containing protease reaction promoter and/or pigment stabilizer | ASAHI KASEI PHARMA CORP (JP) | 2007-08-22 | — | — | CN | disclosed |
| EP-1788081-A1 | REAGENT CONTAINING PROTEASE REACTION PROMOTER AND/OR COLORANT STABILIZER | Asahi Kasei Pharma Corporation (JP) | 2007-05-23 | — | — | EP | disclosed |