Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4880034 | 0.83 | ALDH1A1 (0.47) | ALDH1A1HPGDCYP2C19POLBMAPK1 | |
| SCHEMBL29769835 | 0.82 | L3MBTL1 (0.63) | ALDH1A1HPGDSMN1; SMN2TSHRHTT | |
| SCHEMBL3048096 | 0.82 | ALDH1A1 (0.55) | ALDH1A1HPGDCYP2C19POLBMAPK1 | |
| SCHEMBL1084996 | 0.82 | L3MBTL1 (0.63) | ALDH1A1HPGDSMN1; SMN2TSHRHTT | |
| SCHEMBL6689158 | 0.80 | ALDH1A1 (0.74) | ALDH1A1HPGDCYP2C19POLBMAPK1 | |
| SCHEMBL3825267 | 0.79 | TDP1 (0.46) | MAPK1SMN1; SMN2TSHRHTTMEN1 | |
| SCHEMBL8881117 | 0.79 | MDM4 (0.61) | ALDH1A1HPGDPOLBMAPK1SMN1; SMN2 | |
| SCHEMBL4092413 | 0.79 | TSHR (0.53) | ALDH1A1HPGDMAPK1SMN1; SMN2TSHR | |
| SCHEMBL10448319 | 0.78 | ALDH1A1 (0.50) | ALDH1A1HPGDCYP2C19POLBMAPK1 | |
| SCHEMBL2231380 | 0.78 | ALDH1A1 (0.63) | ALDH1A1HPGDCYP2C19POLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035224-A1 | Betulin derived compounds as anti-feedants for plant pests | VALTION TEKNILLINEN TUTKIMUSKESKUS (FI) | 2012-02-09 | — | — | US | claimed |
| US-20100273801-A1 | BETULIN DERIVED COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS | Valition teknillinen tutikimuskeskus (FI) | 2010-10-28 | — | — | US | claimed |
| US-20100196290-A1 | COMPOSITIONS COMPRISING BETULONIC ACID | VALTION TEKNILLINEN TUTKIMUSKESKUS (FI) | 2010-08-05 | — | — | US | claimed |
| US-20100190795-A1 | BETULIN DERIVED COMPOUNDS USEFUL AS ANTIPROTOZOAL AGENTS | VALTION TEKNILLINEN TUTKIMUSKESKUS (FI) | 2010-07-29 | — | — | US | claimed |
| US-20090022729-A1 | METHODS AND COMPOSITIONS FOR TREATING CARDIAC DYSFUNCTIONS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-01-22 | — | — | US | claimed |
| CN-1261098-C | Inhibitors of p 38-alpha kinase | SCIOS INC (US) | 2006-06-28 | — | — | CN | claimed |
| US-6410540-B1 | HEART AND KIDNEY DISEASES; ANTIINFLAMMATORY AGENTS | SCIOS, INC. | 2002-06-25 | — | — | US | claimed |
| CN-1323209-A | Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase | SCIOS INC (US) | 2001-11-21 | — | — | CN | claimed |
| US-4727079-A | Brain-specific dopaminergic activity involving dihydropyridine carboxamides, dihydroquinoline and isoquinoline carboxamides | UNIVERSITY OF FLORIDA (US) | 1988-02-23 | — | — | US | claimed |
| EP-0114734-B1 | PYRIDINYLMETHYLAMINO-ARYLIC ACIDS | THE UPJOHN COMPANY (US) | 1987-05-13 | — | — | EP | claimed |
| EP-0104727-B1 | PYRIDINYL-SUBSTITUTED BENZIMIDAZOLES AND QUINOXALINES | THE UPJOHN COMPANY (US) | 1986-12-03 | — | — | EP | claimed |
| CN-115244033-A | Novel lappaconitine oxidized derivative and application thereof | 可嘉妮提株式会社 | 2022-10-25 | — | — | CN | disclosed |
| CN-115244034-A | Novel lappaconitine derivative and application thereof | 可嘉妮提株式会社 | 2022-10-25 | — | — | CN | disclosed |
| EP-3219717-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING (R)-N-METHYLNALTREXONE | Progenics Pharmaceuticals, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| US-20170143700-A1 | SYNTHESIS OF (R)-N-METHYLNALTREXONE | PROGENICS PHARMACEUTICALS, INC. (US) | 2017-05-25 | — | — | US | disclosed |
| US-4145441-A | SYMPATHOMIMETIC AMINES EXHIBITING ANTI-HEMORRHOIDAL ACTIVITY | INTERX RESEARCH CORPORATION (US) | 1979-03-20 | — | — | US | disclosed |
| US-4138581-A | BRONCHODILATOR AGENTS, ADRENERGIC STIMULANTS | STERLING DRUGS INC. (US) | 1979-02-06 | — | — | US | disclosed |
| US-4035405-A | Novel synthesis for preparing the hydrochloride salt of selected catecholamine derivatives | INTERX RESEARCH CORPORATION (US) | 1977-07-12 | — | — | US | disclosed |
| US-3983238-A | Substituted pyridinol-containing compositions and methods for the treatment of coccidiosis | SANKYO COMPANY LIMITED (JA) | 1976-09-28 | — | — | US | disclosed |
| US-3935311-A | Substitute pyridinol-containing compositions and methods for the treatment of coccidiosis | SANKYO COMPANY LIMITED (JA) | 1976-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170143700-A1 | SYNTHESIS OF (R)-N-METHYLNALTREXONE | OPRM1, OPRL1, OPRK1 | ALDH1A1 2659/4885HPGD 707/4885CYP2C19 541/4885 |
| US-20090022729-A1 | METHODS AND COMPOSITIONS FOR TREATING CARDIAC DYSFUNCTIONS | TNNI3, MYLK2, FABP3 | ALDH1A1 2037/4885HPGD 329/4885CYP2C19 4813/4885 |
| US-20120035224-A1 | Betulin derived compounds as anti-feedants for plant pests | BET1, BTF3, BROX | ALDH1A1 4661/4885HPGD 2291/4885CYP2C19 4881/4885 |
| US-20100196290-A1 | COMPOSITIONS COMPRISING BETULONIC ACID | BET1, PGGT1B, RABGGTB | ALDH1A1 1999/4885HPGD 1415/4885CYP2C19 450/4885 |
| US-20100273801-A1 | BETULIN DERIVED COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS | BET1, CUTA, BECN1 | ALDH1A1 4151/4885HPGD 2836/4885CYP2C19 2787/4885 |
| US-20100190795-A1 | BETULIN DERIVED COMPOUNDS USEFUL AS ANTIPROTOZOAL AGENTS | BET1, BECN1, PGGT1B | ALDH1A1 3744/4885HPGD 1695/4885CYP2C19 2652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.