SCHEMBL5552255

SCHEMBL5552255

Cc1cc(C)c([Si](OC(C)(C)C)(OC(C)(C)C)OC(C)(C)C)c(C)c1

nearest known ligand 0.32

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
RAPGEF4 Q8WZA2 1/20 0.32
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5138797 0.80 PSMB5 (0.32)
SCHEMBL5027476 0.77 CYP2A6 (0.35) ALDH1A1
SCHEMBL3108980 0.73 ACHE (0.39) KDM4EALDH1A1LMNAGAAMAPT
SCHEMBL2478476 0.68 NOS3 (0.33) KDM4EALDH1A1LMNAGAAMAPT
SCHEMBL5032243 0.68 FFAR4 (0.34) KDM4EALDH1A1LMNAGAAMAPT
SCHEMBL5029868 0.67 TSHR (0.38) ALDH1A1LMNA
SCHEMBL5554342 0.65 NOS2 (0.33) KDM4EALDH1A1LMNAGAAMAPT
SCHEMBL13295957 0.64 RAPGEF4 (0.41) KDM4EALDH1A1LMNAGAAMAPT
SCHEMBL13296036 0.64 RAPGEF4 (0.41) KDM4EALDH1A1LMNAGAAMAPT
SCHEMBL5029804 0.64 NOS2 (0.37) KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070213204-A1 Ziegler-Natta catalyst with in situ-generated donor NOVOLEN TECHNOLOGY HOLDINGS C.V. 2007-09-13 US disclosed