Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27558112 | 0.89 | CHRNB2 (0.56) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL10685331 | 0.88 | ALDH1A1 (0.57) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL19918329 | 0.88 | ALDH1A1 (0.57) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL12835337 | 0.88 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL12173013 | 0.86 | ALDH1A1 (0.54) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL5700875 | 0.85 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL5858822 | 0.84 | ALDH1A1 (0.51) | ALDH1A1HPGDMAPTKMT2ASLC6A2 | |
| SCHEMBL6982978 | 0.83 | ALDH1A1 (0.51) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL9268753 | 0.82 | ALDH1A1 (0.50) | ALDH1A1HPGDMAPTLMNAKMT2A | |
| SCHEMBL7296240 | 0.82 | ALDH1A1 (0.50) | ALDH1A1HPGDMAPTKMT2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118005638-A | Pyrazolo [3,4-d ] pyrimidine structure-containing compound, and preparation method and application thereof | 西安新通药物研究股份有限公司 | 2024-05-10 | — | — | CN | disclosed |
| US-20220241429-A1 | Antifolate-Carrying Nanoparticles and Their Use in Medicine | MIDATECH LTD (GB) | 2022-08-04 | — | — | US | disclosed |
| US-20220047718-A1 | Nanoparticle-Based Therapy of Inflammatory Disorders | MIDATECH LTD (GB) | 2022-02-17 | — | — | US | disclosed |
| WO-2020120785-A1 | ANTIFOLATE-CARRYING NANOPARTICLES AND THEIR USE IN MEDICINE | MIDATECH LTD (GB) | 2020-06-18 | — | — | WO | disclosed |
| WO-2018037120-A1 | PRODRUGS ACTIVATED BY REACTIVE OXYGEN SPECIES FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES AND CANCER | DANMARKS TEKNISKE UNIVERSITET (DK) | 2018-03-01 | — | — | WO | disclosed |
| WO-2018037120-A1 | PRODRUGS ACTIVATED BY REACTIVE OXYGEN SPECIES FOR USE IN THE TREATMENT OF INFLAMMATORY DISEASES AND CANCER | DANMARKS TEKNISKE UNIVERSITET (DK) | 2018-03-01 | — | — | WO | disclosed |
| US-9255072-B2 | Pyrazole compounds and thiazole compounds as protein kinases inhibitors | National Health Rsearch Institutes (TW) | 2016-02-09 | — | — | US | disclosed |
| US-9255072-B2 | Pyrazole compounds and thiazole compounds as protein kinases inhibitors | National Health Rsearch Institutes (TW) | 2016-02-09 | — | — | US | disclosed |
| US-20120225880-A1 | PYRAZOLE COMPOUNDS AND THIAZOLE COMPOUNDS AS PROTEIN KINASES INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2012-09-06 | — | — | US | disclosed |
| US-20120225880-A1 | PYRAZOLE COMPOUNDS AND THIAZOLE COMPOUNDS AS PROTEIN KINASES INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2012-09-06 | — | — | US | disclosed |
| US-6294557-B1 | ANALGESIC AT CENTRAL NERVOUS SYSTEM IN THE MAMMALIAN SUBJECT. ALSO, THESE COMPOUNDS ARE INFLAMMATORY PAIN CAUSED, FOR EXAMPLE BY BURNS (INDUCED BY A CONTACT WITH HEAT, ACID OR THE OTHER RHEUMATISM OR THE LIKE, IN THE SAID SUBJECT. | PFIZER INC. | 2001-09-25 | — | — | US | disclosed |
| US-20010020024-A1 | Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists | ITO FUMITAKA (JP) | 2001-09-06 | — | — | US | disclosed |
| US-20010014683-A1 | Analgesics; side effect reduction | ITO FUMITAKA (JP) | 2001-08-16 | — | — | US | disclosed |
| US-20010011091-A1 | Analgesics | ITO FUMITAKA (JP) | 2001-08-02 | — | — | US | disclosed |
| US-20010009921-A1 | Less tendency to cause drug dependency, analgesic, anesthetic, anti-inflammatory or neuroprotective agent; subtype of opoid receptor | ITO FUMITAKA (JP) | 2001-07-26 | — | — | US | disclosed |
| US-20010008890-A1 | Useful as analgesic, anesthetic, antiinflammatory or neuroprotective agents and in treatment of arthritis, stroke, bowel disease | ITO FUMITAKA (JP) | 2001-07-19 | — | — | US | disclosed |
| WO-2001021577-A2 | MELANIN CONCENTRATING HORMONE ANTAGONIST | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-03-29 | — | — | WO | disclosed |
| US-6201007-B1 | OPIOID KAPPA RECEPTOR AGONISTS; ANALGESICS, ANESTHETICS, NEUROPROTECTIVE AND ANTIINFLAMMATORY AGENTS; STROKES, GASTROINTESTINAL DISORDERS | PFIZER INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0934264-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998012177-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (JP) | 1998-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225880-A1 | PYRAZOLE COMPOUNDS AND THIAZOLE COMPOUNDS AS PROTEIN KINASES INHIBITORS | FLT4, AURKB, AURKA | ALDH1A1 3340/4885HPGD 4352/4885MAPT 2355/4885 |
| US-20010009921-A1 | Less tendency to cause drug dependency, analgesic, anesthetic, anti-inflammatory or neuroprotective agent; subtype of opoid receptor | OPRL1, OPRD1, OPRK1 | ALDH1A1 842/4885HPGD 399/4885MAPT 1579/4885 |
| US-20010011091-A1 | Analgesics | OPRL1, OPRK1, OPRD1 | ALDH1A1 797/4885HPGD 1082/4885MAPT 2858/4885 |
| US-20010020024-A1 | Pyrrolidinyl and pyrrolinyl ethylamine compounds as kappa agonists | OPRK1, OPRL1, OPRD1 | ALDH1A1 2841/4885HPGD 1798/4885MAPT 3756/4885 |
| US-20220047718-A1 | Nanoparticle-Based Therapy of Inflammatory Disorders | MTX1, LANCL1, CD44 | ALDH1A1 587/4885HPGD 755/4885MAPT 373/4885 |
| US-20010014683-A1 | Analgesics; side effect reduction | OPRL1, OPRK1, OPRD1 | ALDH1A1 851/4885HPGD 1278/4885MAPT 3404/4885 |
| US-20220241429-A1 | Antifolate-Carrying Nanoparticles and Their Use in Medicine | FOLR1, FOLR2, SLC19A1 | ALDH1A1 111/4885HPGD 1636/4885MAPT 1643/4885 |
| US-20010008890-A1 | Useful as analgesic, anesthetic, antiinflammatory or neuroprotective agents and in treatment of arthritis, stroke, bowel disease | OPRL1, NAP1L1, OPRK1 | ALDH1A1 1095/4885HPGD 1269/4885MAPT 2088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.