SCHEMBL5583560

SCHEMBL5583560

COc1ccnc(C(=O)Nc2c(C)cc(C(C)(C)C)cc2C)c1O

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.42
MAPT P10636 3/20 0.41
NR1I2 O75469 9/20 0.40
TSHR P16473 2/20 0.40
HTT P42858 1/20 0.40
TP53 P04637 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
FGFR2 P21802 1/20 0.37
HPGD P15428 1/20 0.37
RAB9A P51151 1/20 0.37
PRKCI P41743 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5584058 0.86 NR1I2 (0.50) MAPTNR1I2TSHRTP53SMN1; SMN2
SCHEMBL5583578 0.82 SMN1; SMN2 (0.53) MAPTNR1I2TP53SMN1; SMN2RAB9A
SCHEMBL5583841 0.81 MAPT (0.43) PKMMAPTRAB9A
SCHEMBL5583713 0.80 KDR (0.46) MAPTNR1I2TP53SMN1; SMN2FGFR2
SCHEMBL5583675 0.79 ALDH1A1 (0.48) MAPTNR1I2TSHRHTTSMN1; SMN2
SCHEMBL5583850 0.78 KDR (0.50) PKMMAPTNR1I2HTTTP53
SCHEMBL5583622 0.76 FLT3 (0.53) PKMMAPTTSHRHTTSMN1; SMN2
SCHEMBL5583684 0.76 KDM4E (0.55) PKMMAPTSMN1; SMN2RAB9A
SCHEMBL5583759 0.74 KDR (0.47) MAPTNR1I2TP53SMN1; SMN2FGFR2
SCHEMBL14284458 0.74 EGLN1 (0.41) MAPTTP53SMN1; SMN2HPGDRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US disclosed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP disclosed