SCHEMBL5583622

SCHEMBL5583622

COc1ccnc(C(=O)Nc2cc(C(C)(C)C)on2)c1O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 8/20 0.53
CSF1R P07333 2/20 0.53
RET P07949 1/20 0.53
PDGFRB P09619 1/20 0.53
KIT P10721 1/20 0.53
PDGFRA P16234 1/20 0.53
NPC1 O15118 4/20 0.52
RAB9A P51151 4/20 0.52
SMN1; SMN2 Q16637 3/20 0.51
PKM P14618 1/20 0.51
TSHR P16473 1/20 0.51
HTT P42858 1/20 0.51
KDR P35968 1/20 0.51
RAF1 P04049 1/20 0.47
LMNA P02545 2/20 0.46
POLB P06746 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
BRAF P15056 1/20 0.46
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5584058 0.77 NR1I2 (0.50) SMN1; SMN2TSHRKDRMAPT
SCHEMBL9712857 0.77 CYP1A2 (0.70) FLT3NPC1RAB9ASMN1; SMN2PKM
SCHEMBL5583560 0.76 PKM (0.42) RAB9ASMN1; SMN2PKMTSHRHTT
SCHEMBL5583578 0.76 SMN1; SMN2 (0.53) NPC1RAB9ASMN1; SMN2KDRLMNA
SCHEMBL5583616 0.75 NPC1 (0.63) NPC1RAB9ASMN1; SMN2PKMMEN1
SCHEMBL10804234 0.73 RAF1 (0.62) FLT3NPC1RAB9AHTTRAF1
SCHEMBL5583675 0.73 ALDH1A1 (0.48) NPC1RAB9ASMN1; SMN2TSHRHTT
SCHEMBL5583672 0.73 SCN9A (0.54) CSF1RPDGFRANPC1RAB9ASMN1; SMN2
SCHEMBL14284458 0.72 EGLN1 (0.41) NPC1RAB9ASMN1; SMN2KDRLMNA
SCHEMBL5583719 0.72 NPC1 (0.53) PDGFRANPC1RAB9ASMN1; SMN2PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US disclosed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP disclosed