SCHEMBL5583778

SCHEMBL5583778

COc1ccnc(C(=O)NC(C)(C)CC(C)(C)C)c1O

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.44
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ANO1 Q5XXA6 4/20 0.36
EGLN2 Q96KS0 2/20 0.36
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
ADORA2A P29274 3/20 0.34
ADORA1 P30542 2/20 0.34
AURKA O14965 1/20 0.34
LCK P06239 1/20 0.34
MET P08581 1/20 0.34
KDR P35968 1/20 0.34
TEK Q02763 1/20 0.34
CTSA P10619 1/20 0.34
EGLN1 Q9GZT9 1/20 0.34
GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5583583 0.79 MLYCD (0.44) ANO1EGLN2EGLN1
SCHEMBL5583742 0.78 ROCK2 (0.46) ANO1ADORA2AEGLN1
SCHEMBL14284458 0.77 EGLN1 (0.41) SMN1; SMN2ALDH1A1LMNAAURKALCK
SCHEMBL21262004 0.77 TAS1R3 (0.52) POLBANO1ALDH1A1LMNA
SCHEMBL5583595 0.76 KLKB1 (0.48) POLBHTTSMN1; SMN2ALDH1A1LMNA
SCHEMBL21914940 0.74 APAF1 (0.38) ANO1ALDH1A1LMNAGAA
SCHEMBL18824893 0.74 L3MBTL1 (0.46) POLBHTTSMN1; SMN2ALDH1A1LMNA
SCHEMBL22578946 0.73 MAPT (0.55) POLBHTTSMN1; SMN2ALDH1A1LMNA
SCHEMBL8884435 0.73 TDP1 (0.42) HTTSMN1; SMN2LMNA
SCHEMBL14307432 0.73 ALDH1A1 (0.41) POLBSMN1; SMN2ALDH1A1EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7183278-B1 Picolinamide derivative and harmful organism control agent comprising said picolinamide derivative as active component MEIJI SEIKA KAISHA, LTD. (JP) 2007-02-27 US disclosed
EP-1134214-A1 PICOLINAMIDE DERIVATIVES AND PEST CONTROLLERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2001-09-19 EP disclosed