Glycerin

Glycerin

SCHEMBL5583805

CC(C)O.O.OCC(O)CO

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Glycerin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
THRB known ✓ P10828 1/20 0.44
LMNA P02545 4/20 0.69
ALDH1A1 P00352 3/20 0.69
TDP1 Q9NUW8 2/20 0.53
TSHR P16473 4/20 0.47
OR51E2 Q9H255 1/20 0.35
MAPT P10636 1/20 0.33
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
USP2 O75604 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Glycerin SCHEMBL1081867 0.96 LMNA (0.75) LMNAALDH1A1TDP1TSHRTHRB
Glycerin SCHEMBL8328338 0.96 LMNA (0.75) LMNAALDH1A1TDP1TSHRTHRB
Glycerin SCHEMBL27630288 0.92 LMNA (0.69) LMNAALDH1A1TDP1TSHRTHRB
Glycerin SCHEMBL17698397 0.89 LMNA (0.64) LMNAALDH1A1TDP1TSHRTHRB
Glycerin SCHEMBL28180127 0.89 LMNA (0.64) LMNAALDH1A1TDP1TSHRTHRB
Glycerin SCHEMBL3132908 0.89 TDP1 (0.71) LMNAALDH1A1TDP1TSHRTHRB
Glycerin SCHEMBL8504999 0.89 TDP1 (0.71) LMNAALDH1A1TDP1TSHRTHRB
Glycerin SCHEMBL8991622 0.88
Glycerin SCHEMBL7624987 0.88 LMNA (0.75) LMNAALDH1A1TDP1TSHRTHRB
Glycerin SCHEMBL187320 0.88

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7183456-B2 Water-absorbent resin and production process therefor NIPPON SHOKUBAI CO., LTD. (JP) 2007-02-27 US disclosed
US-20040186244-A1 Water-absorbent resin and production process therefor HATSUDA TAKUMI (JP) 2004-09-23 US disclosed
US-6720389-B2 SPRAY-BLENDING A WATER-ABSORBENT RESIN AND A LIQUID MATERIAL SPRAY; SPRAY PATTERN IS A CIRCULAR AND HOLLOW CONE SHAPE OR A DOUBLE-CONVEX-LENS AND ELLIPTIC CONE SHAPE; HEAT TREATMENT; SURFACE CROSSLINKING NIPPON SHOKUBAI CO., LTD. (JP) 2004-04-13 US disclosed
US-20020061978-A1 Water-absorbent resin and production process therefor NIPPON SHOKUBAI CO., LTD. (JP) 2002-05-23 US disclosed
US-4591583-A TREATING VIRAL INFECTIONS ASTRA LAKEMEDEL AKTIEBOLAG (SE) 1986-05-27 US disclosed
US-4536400-A VIRICIDES ASTRA LAKEMEDEL AKTIEBOLAG (SE) 1985-08-20 US disclosed
US-4386081-A VIRICIDE ASTRA LAKEMEDEL AKTIEBOLAG (SE) 1983-05-31 US disclosed
US-4372894-A VIRICIDES ASTRA LAKEMEDEL AKTIEBOLAG (SE) 1983-02-08 US disclosed
EP-0003007-B1 ALIPHATIC DERIVATIVES OF PHOSPHONOFORMIC ACID, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR COMBATING VIRUS INFECTIONS Astra Läkemedel Aktiebolag (SE) 1982-04-07 EP disclosed
EP-0003007-A2 Aliphatic derivatives of phosphonoformic acid, pharmaceutical compositions and methods for combating virus infections Astra Läkemedel Aktiebolag (SE) 1979-07-11 EP disclosed