Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
| ▸ | STAT6 | P42226 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9107126 | 0.81 | TSHR (0.32) | HTR7 | |
| SCHEMBL28671856 | 0.79 | MAPT (0.30) | HTR7 | |
| SCHEMBL8182848 | 0.78 | ALDH1A1 (0.42) | — | |
| SCHEMBL5597174 | 0.77 | L3MBTL1 (0.36) | CA2 | |
| SCHEMBL10292594 | 0.76 | ALDH1A1 (0.31) | — | |
| SCHEMBL9804253 | 0.74 | — | — | |
| SCHEMBL13889986 | 0.72 | — | — | |
| SCHEMBL9106316 | 0.72 | NAAA (0.33) | TP53 | |
| SCHEMBL31207769 | 0.71 | CA2 (0.35) | CA2 | |
| SCHEMBL25382273 | 0.70 | APLNR (0.48) | CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266899-B1 | Rapamycin hdroxyesters, process for their preparation and pharmaceutical compositions containing them | WYETH CORP (US) | 2007-01-03 | — | — | EP | claimed |