Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 5/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599554 | 0.82 | MTNR1A (0.36) | MTNR1AHDAC1HDAC6CACNA1GCACNA1H | |
| SCHEMBL5599732 | 0.75 | SMN1; SMN2 (0.38) | HTR2AALDH1A1MAPTOPRM1 | |
| SCHEMBL5779471 | 0.71 | POLB (0.37) | MAPT | |
| SCHEMBL5592351 | 0.68 | HDAC1 (0.42) | HDAC1HDAC6ALDH1A1OPRM1KCNH2 | |
| SCHEMBL8707482 | 0.67 | HTR2C (0.38) | HTR2CMAPK1 | |
| SCHEMBL1670310 | 0.65 | HTR2C (0.49) | CACNA1GCACNA1HCACNA1IHTR2CMAPK1 | |
| SCHEMBL6649033 | 0.64 | HTR2C (0.40) | HTR2CMAPK1 | |
| SCHEMBL5778898 | 0.63 | FKBP1A (0.42) | CACNA1GCACNA1HCACNA1IBCHEALDH1A1 | |
| SCHEMBL2801668 | 0.63 | NOTUM (0.40) | SIGMAR1MAPK1OPRM1 | |
| SCHEMBL14713128 | 0.63 | SIGMAR1 (0.36) | SIGMAR1HTR2AHTR2CUSP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |