Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 7/20 | 0.36 |
| ▸ | TPSD1 | Q9BZJ3 | 7/20 | 0.36 |
| ▸ | TPSG1 | Q9NRR2 | 7/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599302 | 0.72 | MEN1 (0.45) | ALDH1A1MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL5599362 | 0.71 | TPSAB1 (0.37) | ALDH1A1TPSAB1TPSD1TPSG1AKR1C3 | |
| SCHEMBL5599427 | 0.70 | DPP4 (0.36) | FKBP1AALDH1A1AKR1C3MAPTMEN1 | |
| SCHEMBL8710585 | 0.66 | SMYD3 (0.54) | FKBP1ATSHRALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL6670425 | 0.65 | TP53 (0.42) | — | |
| SCHEMBL27212906 | 0.65 | HTT (0.37) | TSHRBCHE | |
| SCHEMBL1670310 | 0.65 | HTR2C (0.49) | CACNA1GCACNA1HCACNA1ISMN1; SMN2 | |
| SCHEMBL5578677 | 0.65 | SIGMAR1 (0.50) | FKBP1A | |
| SCHEMBL5599554 | 0.65 | MTNR1A (0.36) | ALDH1A1CACNA1GCACNA1HCACNA1IMAPT | |
| SCHEMBL5598985 | 0.63 | MTNR1A (0.36) | ALDH1A1CACNA1GCACNA1HCACNA1IMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |