Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PTPRB | P23467 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | CTSV | O60911 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5603320 | 0.92 | PNMT (0.53) | PNMTALDH1A1HPGDMDM2POLB | |
| SCHEMBL5600839 | 0.90 | PNMT (0.50) | PNMTHCAR2APEX1CTSLCTSV | |
| SCHEMBL3348204 | 0.88 | PNMT (0.49) | PNMTALDH1A1HPGDMDM2POLB | |
| SCHEMBL2427863 | 0.86 | PNMT (0.46) | PNMTALDH1A1HPGDMDM2POLB | |
| SCHEMBL2430113 | 0.85 | PNMT (0.45) | PNMTALDH1A1HPGDMDM2POLB | |
| SCHEMBL2421563 | 0.85 | PNMT (0.45) | PNMTALDH1A1HPGDMDM2POLB | |
| SCHEMBL9755822 | 0.83 | MMP8 (0.53) | ALDH1A1MDM2POLBPTPRBPPARG | |
| SCHEMBL2424055 | 0.82 | HPGD (0.45) | PNMTALDH1A1HPGDMDM2HCAR2 | |
| SCHEMBL19803579 | 0.82 | PNMT (0.51) | PNMTALDH1A1HPGDPOLBHCAR2 | |
| SCHEMBL8594261 | 0.82 | PNMT (0.51) | PNMTALDH1A1HPGDPOLBHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1541545-B1 | Malonic acid monomethyl derivates and production process thereof | DAICEL CHEM (JP) | 2007-06-27 | — | — | EP | disclosed |
| US-7208621-B2 | Malonic acid monomethyl derivatives and production process thereof | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2007-04-24 | — | — | US | disclosed |
| EP-1508562-B1 | Novel acid halide derivatives, their production, and production of indanonecarboxylic acid esters using the same | DAICEL CHEM (JP) | 2006-12-27 | — | — | EP | disclosed |
| US-20060252957-A1 | Monomethyl m-halobenzylmalonate useful for the production of an indanonecarboxylic acid ester having a halogen atom on the indanone ring. | NOSE SATORU | 2006-11-09 | — | — | US | disclosed |
| US-7109369-B2 | Malonic acid monomethyl derivatives and production process thereof | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2006-09-19 | — | — | US | disclosed |
| US-6916946-B2 | Acid halide derivatives, their production, and production of indanonecarboxylic acid esters using the same | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2005-07-12 | — | — | US | disclosed |
| EP-1541545-A1 | Malonic acid monomethyl derivates and production process thereof | Daicel Chemical Industries, Ltd. (JP) | 2005-06-15 | — | — | EP | disclosed |
| US-20050124825-A1 | Novel malonic acid monomethyl derivatives and production process thereof | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2005-06-09 | — | — | US | disclosed |
| US-20050043568-A1 | Novel acid halide derivatives, their production, and production of indanonecarboxylic acid esters using the same | DAICEL CHEMICAL INDUSTRIES, LTD. (JP) | 2005-02-24 | — | — | US | disclosed |
| EP-1508562-A1 | Novel acid halide derivatives, their production, and production of indanonecarboxylic acid esters using the same | Daicel Chemical Industries, Ltd. (JP) | 2005-02-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043568-A1 | Novel acid halide derivatives, their production, and production of indanonecarboxylic acid esters using the same | DDT, BCKDK, CYP4A22 | PNMT 4851/4885ALDH1A1 83/4885HPGD 448/4885 |
| US-20050124825-A1 | Novel malonic acid monomethyl derivatives and production process thereof | ME1, ME3, ME2 | PNMT 3301/4885ALDH1A1 276/4885HPGD 782/4885 |
| US-20060252957-A1 | Monomethyl m-halobenzylmalonate useful for the production of an indanonecarboxylic acid ester having a halogen atom on the indanone ring. | BCKDK, ME1, MGAM | PNMT 2954/4885ALDH1A1 524/4885HPGD 384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.