Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608967 | 0.88 | SNCA (0.39) | SNCAALDH1A1MAPTDAOATM | |
| SCHEMBL5608587 | 0.86 | SNCA (0.39) | SNCAALDH1A1POLBMAPTDAO | |
| SCHEMBL5608922 | 0.83 | MAOA (0.40) | SNCAALDH1A1HIF1AMAOAMAOB | |
| SCHEMBL5608778 | 0.73 | ALOX15 (0.41) | SNCAALDH1A1HIF1AMAOAMAOB | |
| SCHEMBL5608461 | 0.73 | GABRA1 (0.34) | SNCAALDH1A1POLBMAPTCASP6 | |
| SCHEMBL5608736 | 0.69 | TSHR (0.40) | ALDH1A1VCAM1CYP3A4 | |
| SCHEMBL14880650 | 0.64 | ALDH1A1 (0.60) | SNCAALDH3A1ALDH1A1MAPTHIF1A | |
| SCHEMBL5547199 | 0.63 | ALDH1A1 (0.40) | SNCAALDH3A1ALDH1A1IDO1TDO2 | |
| SCHEMBL5545829 | 0.63 | SNCA (0.40) | SNCAALDH3A1ALDH1A1IDO1TDO2 | |
| SCHEMBL6820729 | 0.62 | PTPRC (0.50) | ALDH1A1POLBMAPTDAOHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |