Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | GFER | P55789 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | SNCA | P37840 | 1/20 | 0.30 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608778 | 0.78 | ALOX15 (0.41) | MAOAMAOBALDH1A1SNCA | |
| SCHEMBL5608922 | 0.76 | MAOA (0.40) | MAOAMAOBALDH1A1MEN1KMT2A | |
| SCHEMBL5608967 | 0.74 | SNCA (0.39) | ALDH1A1TDP1MEN1MAPTKMT2A | |
| SCHEMBL5608587 | 0.74 | SNCA (0.39) | ALDH1A1POLBTDP1MEN1MAPT | |
| SCHEMBL5608736 | 0.74 | TSHR (0.40) | ALDH1A1 | |
| SCHEMBL5608745 | 0.73 | SNCA (0.40) | MAOAMAOBALDH1A1POLBTDP1 | |
| SCHEMBL7645214 | 0.69 | GABRA1 (0.41) | GABRA1GABRB2ALDH1A1POLBTDP1 | |
| SCHEMBL9280592 | 0.67 | HCAR3 (0.38) | GABRA1GABRB2ALDH1A1POLBTDP1 | |
| SCHEMBL9282606 | 0.67 | TSHR (0.42) | GABRA1GABRB2ALDH1A1TDP1SNCA | |
| SCHEMBL9001711 | 0.67 | SNCA (0.53) | GABRA1GABRB2ALDH1A1POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |