SCHEMBL5620587

SCHEMBL5620587

Cc1cc(C#N)cc(C(=O)NC2CC2)c1NC(=O)c1cc(Cl)nn1-c1ncccc1Cl

nearest known ligand 0.53

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
RORC P51449 3/20 0.40
PDE4B Q07343 9/20 0.39
NTRK1 P04629 1/20 0.39
MALT1 Q9UDY8 1/20 0.38
PDE4D Q08499 4/20 0.37
GRM4 Q14833 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
IRAK4 Q9NWZ3 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13318551 0.92 RORC (0.39) RORCPDE4BNTRK1MALT1PDE4D
SCHEMBL11893160 0.92 DHODH (0.40) RORCPDE4BNTRK1MALT1PDE4D
SCHEMBL15906335 0.90 NTRK1 (0.40) PDE4BNTRK1MALT1PDE4DMEN1
SCHEMBL563502 0.89 KMT2A (0.36) PDE4BMALT1PDE4DKMT2A
SCHEMBL30845280 0.89 KMT2A (0.36) PDE4BMALT1PDE4DKMT2A
SCHEMBL961226 0.87 SLC2A1 (0.38) PDE4BNTRK1MALT1PDE4DKMT2A
SCHEMBL31060063 0.87 SLC2A1 (0.38) PDE4BNTRK1MALT1PDE4DKMT2A
SCHEMBL11893224 0.87 PKM (0.40) RORCPDE4BPDE4DMEN1KMT2A
SCHEMBL563295 0.87 KCNH2 (0.37) PDE4BMALT1PDE4DKMT2AIRAK4
SCHEMBL30078303 0.87 KCNH2 (0.37) PDE4BMALT1PDE4DKMT2AIRAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7247647-B2 Cyano anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-07-24 US claimed
US-8993480-B2 Active ingredient combinations with insecticidal properties BAYER CROPSCIENCE AG (DE) 2015-03-31 US disclosed
US-8298989-B2 Active ingredient combinations with insecticidal properties BAYER CROPSCIENCE AG (DE) 2012-10-30 US disclosed
US-20120190544-A1 ACTIVE INGREDIENT COMBINATIONS WITH INSECTICIDAL PROPERTIES BAYER CROPSCIENCE AG (DE) 2012-07-26 US disclosed
US-7977278-B2 Suspension concentrates BAYER CROPSCIENCE AG (DE) 2011-07-12 US disclosed
US-20100099717-A1 SUSPENSION CONCENTRATES FOR IMPROVING THE ROOT ABSORPTION OF AGROCHEMICAL ACTIVE INGREDIENTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-04-22 US disclosed
US-20100010051-A1 SUSPENSION CONCENTRATES BAYER CROPSCIENCE AG (DE) 2010-01-14 US disclosed
US-20090275471-A1 ACTIVE INGREDIENT COMBINATIONS WITH INSECTICIDAL PROPERTIES BAYER CROPSCIENCE AG (DE) 2009-11-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100099717-A1 SUSPENSION CONCENTRATES FOR IMPROVING THE ROOT ABSORPTION OF AGROCHEMICAL ACTIVE INGREDIENTS CROCC, SLC19A1, ABCB11 RORC 1185/4885PDE4B 2167/4885NTRK1 3330/4885
US-20120190544-A1 ACTIVE INGREDIENT COMBINATIONS WITH INSECTICIDAL PROPERTIES AADAC, ACHE, NAAA RORC 3108/4885PDE4B 626/4885NTRK1 4771/4885
US-20100010051-A1 SUSPENSION CONCENTRATES AKR7A2, CBR3, DCXR RORC 3113/4885PDE4B 439/4885NTRK1 4144/4885
US-20090275471-A1 ACTIVE INGREDIENT COMBINATIONS WITH INSECTICIDAL PROPERTIES AADAC, ACHE, NAAA RORC 3108/4885PDE4B 626/4885NTRK1 4771/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.