Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 8/20 | 0.35 |
| ▸ | CA2 | P00918 | 8/20 | 0.35 |
| ▸ | CA5A | P35218 | 7/20 | 0.35 |
| ▸ | CA7 | P43166 | 7/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 7/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3559017 | 0.79 | MAOA (0.42) | CA1CA2CA5ACA12CA9 | |
| SCHEMBL1874184 | 0.78 | CYP2C9 (0.42) | CISD1L3MBTL1KDM4ECYP2C9CA1 | |
| SCHEMBL5679966 | 0.71 | CA2 (0.39) | CYP2C9CA1CA2CA5ACA7 | |
| SCHEMBL19387618 | 0.71 | CA2 (0.36) | KDM4ECA1CA2CA12CA9 | |
| SCHEMBL10869347 | 0.70 | CA1 (0.43) | CISD1L3MBTL1KDM4ECYP2C9CA1 | |
| SCHEMBL9414144 | 0.68 | CYP2C9 (0.44) | KDM4ECYP2C9KMT2APOLBALDH1A1 | |
| SCHEMBL28225354 | 0.67 | L3MBTL1 (0.61) | L3MBTL1KDM4ECA1CA2CA5A | |
| SCHEMBL15274410 | 0.65 | CYP2C9 (0.44) | KDM4ECYP2C9MEN1KMT2APOLB | |
| SCHEMBL28862587 | 0.65 | CA1 (0.46) | L3MBTL1KDM4ECYP2C9CA1CA2 | |
| SCHEMBL23200538 | 0.65 | ALDH1A1 (0.42) | KDM4ECA1CA2CA5ACA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613313-A1 | 2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-4,5!-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004093873-A1 | 2-PHENYL-BENZIMIDAZOL AND 2-PHENYL-IMIDAZO-`4,5!-PYRIDINE DERIVATIVES AS CHECKPOINT KINASE CDS1 (CHK2) INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-11-04 | — | — | WO | disclosed |