Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | LGALS9 | O00182 | 1/20 | 0.42 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.42 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2969544 | 1.00 | TDP1 (0.50) | TDP1SCN1ASCN2ASCN3AMAPT | |
| SCHEMBL8458023 | 1.00 | TDP1 (0.50) | TDP1SCN1ASCN2ASCN3AMAPT | |
| SCHEMBL5800186 | 0.90 | TDP1 (0.44) | TDP1SCN1ASCN2ASCN3AMAPT | |
| SCHEMBL8158299 | 0.90 | TDP1 (0.44) | TDP1SCN1ASCN2ASCN3AMAPT | |
| SCHEMBL1751897 | 0.81 | LMNA (0.48) | TDP1MAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL637664 | 0.81 | LMNA (0.48) | TDP1MAPTKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8461979 | 0.81 | RAB9A (0.42) | MAPTKMT2ASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL8461105 | 0.80 | PARP1 (0.46) | TDP1MAPTKMT2APOLBALDH1A1 | |
| SCHEMBL24279365 | 0.76 | SCN1A (0.46) | TDP1SCN1ASCN2ASCN3AMAPT | |
| SCHEMBL4544916 | 0.72 | SCN1A (0.75) | TDP1SCN1ASCN2ASCN3AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370754-B2 | Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide | CALITHERA BIOSCIENCES, INC. (US) | 2022-06-28 | — | — | US | disclosed |
| EP-3621954-B1 | METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE | CALITHERA BIOSCIENCES INC (US) | 2022-03-09 | — | — | EP | disclosed |
| US-20210155589-A1 | METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE | CALITHERA BIOSCIENCES, INC. (US) | 2021-05-27 | — | — | US | disclosed |
| US-10906872-B2 | Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide | CALITHERA BIOSCIENCES, INC. (US) | 2021-02-02 | — | — | US | disclosed |
| US-20200087255-A1 | METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE | CALITHERA BIOSCIENCES, INC. (US) | 2020-03-19 | — | — | US | disclosed |
| US-20060270847-A1 | Process for producing nitrogenous heterocyclic compound | TORAY FINE CHEMICALS CO., LTD. (JP) | 2006-11-30 | — | — | US | disclosed |
| EP-1640364-A1 | PROCESS FOR PRODUCING NITROGENOUS HETEROCYCLIC COMPOUND | Toray Fine Chemicals Co., Ltd. (JP) | 2006-03-29 | — | — | EP | disclosed |
| EP-0600714-B1 | Process for producing O,O'-diacyltartaric anhydride and process for producing O,O'-diacyltartaric acid | TORAY INDUSTRIES (JP) | 1999-08-18 | — | — | EP | disclosed |
| EP-0924188-A1 | Production of 0,0'-diacyltartaric acid crystals | TORAY INDUSTRIES, INC. (JP) | 1999-06-23 | — | — | EP | disclosed |
| US-5451687-A | Process for producing O,O'-diacyltartaric anhydride and process for producing O,O'-diacyltartaric acid | TORAY INDUSTRIES, INC. (JP) | 1995-09-19 | — | — | US | disclosed |
| EP-0600714-A1 | Process for producing O,O'-diacyltartaric anhydride and process for producing O,O'-diacyltartaric acid | TORAY INDUSTRIES, INC. (JP) | 1994-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200087255-A1 | METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE | TERT, CTPS1, CTPS2 | TDP1 2064/4885SCN1A 2132/4885SCN2A 1512/4885 |
| US-10906872-B2 | Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide | TERT, CTPS1, CTPS2 | TDP1 2064/4885SCN1A 2132/4885SCN2A 1512/4885 |
| US-11370754-B2 | Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide | TERT, CTPS1, CTPS2 | TDP1 2064/4885SCN1A 2132/4885SCN2A 1512/4885 |
| US-20060270847-A1 | Process for producing nitrogenous heterocyclic compound | HNMT, HRH4, QDPR | TDP1 3428/4885SCN1A 1705/4885SCN2A 750/4885 |
| US-20210155589-A1 | METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE | TERT, CTPS1, CTPS2 | TDP1 2064/4885SCN1A 2132/4885SCN2A 1512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.