Sugi Predict

Sugi Predict / Compounds / SCHEMBL5698265

SCHEMBL5698265

SCHEMBL5698265

Cc1cc(O)c(Br)cc1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 3/20 0.43
▸ CYP3A4 P08684 3/20 0.43
▸ KDM4E B2RXH2 2/20 0.43
▸ MAPT P10636 2/20 0.43
▸ MAPK1 P28482 2/20 0.43
▸ ALOX12 P18054 2/20 0.43
▸ ALDH1A1 P00352 1/20 0.43
▸ CYP1A2 P05177 1/20 0.43
▸ CYP2D6 P10635 1/20 0.43
▸ G6PD P11413 1/20 0.43
▸ CYP2C9 P11712 1/20 0.43
▸ PKM P14618 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ CYP2C19 P33261 1/20 0.43
▸ CCR6 P51684 1/20 0.43
▸ HIF1A Q16665 1/20 0.43
▸ NPSR1 Q6W5P4 1/20 0.43
▸ HSD17B10 Q99714 1/20 0.43
▸ TDP1 Q9NUW8 2/20 0.36
▸ TP53 P04637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1146850 0.86 ALOX15 (0.55) ALOX15CYP3A4KDM4EMAPTMAPK1
SCHEMBL12572587 0.86 ALOX15 (0.48) ALOX15CYP3A4KDM4EMAPTMAPK1
SCHEMBL6743198 0.86 ALOX15 (0.40) ALOX15CYP3A4KDM4EMAPTMAPK1
SCHEMBL29446755 0.86 ALOX15 (0.55) ALOX15CYP3A4KDM4EMAPTMAPK1
SCHEMBL10907457 0.86 ALOX15 (0.42) ALOX15CYP3A4KDM4EMAPTMAPK1
SCHEMBL22401850 0.81 CYP3A4 (0.48) ALOX15CYP3A4KDM4EMAPTMAPK1
SCHEMBL282020 0.80 ALOX15 (0.55) ALOX15CYP3A4KDM4EMAPTMAPK1
SCHEMBL1438611 0.79 KDM1A (0.37) ALOX15CYP3A4KDM4EMAPTMAPK1
SCHEMBL4976763 0.79 LMNA (0.52) ALOX15CYP3A4KDM4EMAPTMAPK1
SCHEMBL14049224 0.79 LMNA (0.47) ALOX15CYP3A4KDM4EMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116478199-A Bimetallic catalyst and preparation method thereof, and preparation method of high molecular weight olefin polymer 万华化学集团股份有限公司 2023-07-25 — — CN claimed
US-12187681-B2 Ion channel antagonists/blockers and uses thereof SHANGHAI EAST HOSPITAL (CN) 2025-01-07 — — US disclosed
US-20240294542-A1 NLRP3 INFLAMMASOME INHIBITOR AND APPLICATION THEREOF TRANSTHERA SCIENCES (NANJING), INC. (CN) 2024-09-05 — — US disclosed
CN-114401935-B Ion channel antagonists/blockers and uses thereof 上海市东方医院（同济大学附属东方医院） 2024-04-05 — — CN disclosed
CN-116478199-A Bimetallic catalyst and preparation method thereof, and preparation method of high molecular weight olefin polymer 万华化学集团股份有限公司 2023-07-25 — — CN disclosed
US-20230023559-A1 ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS D. E. SHAW RESEARCH, LLC (US) 2023-01-26 — — US disclosed
US-20230015875-A1 Ion Channel Antagonists/Blockers and Uses Thereof SHANGHAI EAST HOSPITAL (CN) 2023-01-19 — — US disclosed
WO-2022253326-A1 NLRP3 INFLAMMASOME INHIBITOR AND APPLICATION THEREOF 药捷安康(南京)科技股份有限公司 2022-12-08 — — WO disclosed
CN-115433163-A NLRP3 inflammasome inhibitor and application thereof 药捷安康(南京)科技股份有限公司 2022-12-06 — — CN disclosed
EP-4041229-A1 ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS D.E. Shaw Research, LLC (US) 2022-08-17 — — EP disclosed
US-20140051692-A1 Inhibitors of Human Immunodeficiency Virus Replication VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) 2014-02-20 — — US disclosed
US-20140051692-A1 Inhibitors of Human Immunodeficiency Virus Replication VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) 2014-02-20 — — US disclosed
US-20140051692-A1 Inhibitors of Human Immunodeficiency Virus Replication VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) 2014-02-20 — — US disclosed
WO-2014028384-A1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION BRISTOL-MYERS SQUIBB COMPANY (US) 2014-02-20 — — WO disclosed
WO-2014028384-A1 INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION BRISTOL-MYERS SQUIBB COMPANY (US) 2014-02-20 — — WO disclosed
WO-2012090969-A1 AMIDINE COMPOUNDS AND USE THEREOF FOR PLANT DISEASE CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-07-05 — — WO disclosed
EP-1677788-A1 ALKYNES III AstraZeneca AB (SE) 2006-07-12 — — EP disclosed
WO-2005044265-A1 ALKYNES III ASTRAZENECA AB (SE) 2005-05-19 — — WO disclosed
EP-0443533-B1 Positive photoresist composition FUJI PHOTO FILM CO LTD (JP) 1998-09-30 — — EP disclosed
EP-0443533-A2 Positive photoresist composition FUJI PHOTO FILM CO., LTD. (JP) 1991-08-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240294542-A1 NLRP3 INFLAMMASOME INHIBITOR AND APPLICATION THEREOF NLRP3, NLRP1, PYCARD ALOX15 704/4885CYP3A4 1757/4885KDM4E 3867/4885
US-20230015875-A1 Ion Channel Antagonists/Blockers and Uses Thereof CACNA1F, CACNA1S, CACNA1D ALOX15 1017/4885CYP3A4 538/4885KDM4E 3795/4885
US-12187681-B2 Ion channel antagonists/blockers and uses thereof CACNA1F, CACNA1S, CACNA1D ALOX15 1017/4885CYP3A4 538/4885KDM4E 3795/4885
US-20230023559-A1 ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS KCNJ2, KCNA3, KCNH3 ALOX15 4419/4885CYP3A4 422/4885KDM4E 241/4885
US-20140051692-A1 Inhibitors of Human Immunodeficiency Virus Replication EIF2AK2, RTF2, MAVS ALOX15 2916/4885CYP3A4 1719/4885KDM4E 2143/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.