Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL129594 | 0.84 | AMY1A (0.51) | MEN1KMT2ACYP1A2AMY1AALDH1A1 | |
| SCHEMBL21352066 | 0.82 | TUBB4A (0.46) | MEN1KMT2ACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL2044950 | 0.80 | KDM4E (0.40) | MEN1KMT2ACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL7672288 | 0.80 | CYP1A1 (0.42) | MEN1KMT2ACYP1A1CYP1A2CYP1B1 | |
| SCHEMBL30178662 | 0.80 | ALDH1A1 (0.63) | CYP1A1CYP1A2CYP1B1ERN1ALDH1A1 | |
| SCHEMBL11173 | 0.80 | ALDH1A1 (0.63) | CYP1A1CYP1A2CYP1B1ERN1ALDH1A1 | |
| SCHEMBL3810446 | 0.79 | ALDH1A1 (0.43) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3861430 | 0.79 | HPGD (0.51) | MEN1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL24851672 | 0.79 | ALDH1A1 (0.48) | CYP1A1CYP1A2CYP1B1ERN1ALDH1A1 | |
| SCHEMBL10515789 | 0.78 | CYP1A2 (0.50) | MEN1KMT2ACYP1A1CYP1A2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836490-B1 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER (US) | 2017-06-14 | — | — | EP | disclosed |
| US-9394285-B2 | Indole and indazole compounds that activate AMPK | PFIZER INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-20160016940-A1 | Indole and Indazole Compounds that Activate AMPK | PFIZER, INC. (US) | 2016-01-21 | — | — | US | disclosed |
| EP-2970177-A1 | INDOLE COMPOUNDS THAT ACTIVATE AMPK | Pfizer Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2836490-A2 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | Pfizer Inc. (US) | 2015-02-18 | — | — | EP | disclosed |
| US-20150038484-A1 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER INC. (US) | 2015-02-05 | — | — | US | disclosed |
| US-20140364398-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | PFIZER INC. (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364398-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | PFIZER INC. (US) | 2014-12-11 | — | — | US | disclosed |
| US-20140364398-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | PFIZER INC. (US) | 2014-12-11 | — | — | US | disclosed |
| US-8889730-B2 | Indole and indazole compounds that activate AMPK | PFIZER INC. (US) | 2014-11-18 | — | — | US | disclosed |
| US-8853258-B2 | C-linked hydroxamic acid derivatives useful as antibacterial agents | PFIZER INC. (US) | 2014-10-07 | — | — | US | disclosed |
| WO-2014140704-A1 | INDOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2013153479-A2 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER INC. (US) | 2013-10-17 | — | — | WO | disclosed |
| US-20130267493-A1 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PFIZER INC. (US) | 2013-10-10 | — | — | US | disclosed |
| EP-2488489-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| US-20120202777-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | BROWN MATTHEW FRANK (US) | 2012-08-09 | — | — | US | disclosed |
| US-20120202777-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | BROWN MATTHEW FRANK (US) | 2012-08-09 | — | — | US | disclosed |
| US-20120202777-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | BROWN MATTHEW FRANK (US) | 2012-08-09 | — | — | US | disclosed |
| WO-2011045703-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2011-04-21 | — | — | WO | disclosed |
| WO-2011045703-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2011-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202777-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | HAX1, LPXN, AGXT | MEN1 4345/4885KMT2A 387/4885CYP1A1 3767/4885 |
| US-20160016940-A1 | Indole and Indazole Compounds that Activate AMPK | PRKAG1, PRKAG3, PRKAG2 | MEN1 4037/4885KMT2A 1740/4885CYP1A1 858/4885 |
| US-20150038484-A1 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PRKAG1, PRKAG3, PRKAG2 | MEN1 4037/4885KMT2A 1740/4885CYP1A1 858/4885 |
| US-20130267493-A1 | INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK | PRKAG1, PRKAG3, PRKAG2 | MEN1 4037/4885KMT2A 1740/4885CYP1A1 858/4885 |
| US-20140364398-A1 | C-Linked Hydroxamic Acid Derivatives Useful As Antibacterial Agents | LCT, AGXT, PRXL2A | MEN1 4357/4885KMT2A 636/4885CYP1A1 4461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.