Sugi Predict

Sugi Predict / Compounds / SCHEMBL572

SCHEMBL572

SCHEMBL572

CCOC(=O)CC(=O)c1ccc(C)cc1

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 6/20 0.58
▸ NPC1 O15118 5/20 0.58
▸ RAB9A P51151 5/20 0.58
▸ MEN1 O00255 2/20 0.58
▸ ALDH1A1 P00352 4/20 0.54
▸ KDM4E B2RXH2 2/20 0.54
▸ MAPT P10636 4/20 0.53
▸ GAA P10253 4/20 0.52
▸ MGAM O43451 1/20 0.52
▸ SI P14410 1/20 0.52
▸ MGAM2 Q2M2H8 1/20 0.52
▸ GSK3B P49841 1/20 0.52
▸ TSHR P16473 1/20 0.50
▸ HPGD P15428 1/20 0.49
▸ TDP1 Q9NUW8 2/20 0.48
▸ HSD17B10 Q99714 1/20 0.48
▸ LMNA P02545 1/20 0.46
▸ L3MBTL1 Q9Y468 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7411741 0.91 KMT2A (0.53) KMT2ANPC1RAB9AMEN1ALDH1A1
SCHEMBL11515591 0.87 TSHR (0.66) KMT2ANPC1RAB9AMEN1ALDH1A1
SCHEMBL8085697 0.87 CA12 (0.61) KMT2ANPC1RAB9AMEN1ALDH1A1
SCHEMBL8585196 0.87 ALDH1A1 (0.53) KMT2ANPC1RAB9AMEN1ALDH1A1
Malonic Acid Diethyl Ester SCHEMBL8399632 0.86 GAA (0.71) KMT2ARAB9AMEN1ALDH1A1MAPT
SCHEMBL23149729 0.85 PARP10 (0.53) KMT2ANPC1RAB9AMEN1ALDH1A1
SCHEMBL13634 0.85 KMT2A (0.66) KMT2ANPC1RAB9AMEN1ALDH1A1
SCHEMBL276803 0.85 SMN1; SMN2 (0.61) KMT2ANPC1RAB9AMEN1ALDH1A1
SCHEMBL314260 0.85 KMT2A (0.54) KMT2ANPC1RAB9AMEN1ALDH1A1
SCHEMBL13516645 0.85 ALDH1A1 (0.55) KMT2ANPC1RAB9AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 167 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080262247-A1 Process for preparing arylaminopropanols ECKERT MARKUS 2008-10-23 — — US claimed
US-20030225153-A1 Process for preparing arylaminopropanols LANXESS DEUTSCHLAND GMBH (DE) 2003-12-04 — — US claimed
CN-1445224-A Process for preparing arylaminopropanols BAYER AG (DE) 2003-10-01 — — CN claimed
EP-1346977-A1 Method for producing aryl-aminopropanols Bayer Aktiengesellschaft (DE) 2003-09-24 — — EP claimed
US-12378200-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ORSOBIO, INC. (US) 2025-08-05 — — US disclosed
CN-112209907-B Method for synthesizing dihydrofuran containing 1, 3-indenodione spiro framework by utilizing microchannel reaction device 南京先进生物材料与过程装备研究院有限公司 2025-03-18 — — CN disclosed
CN-119330862-A Synthesis method of 2- (benzenesulfonamide) -3-oxo-3-phenylpropionate compound 郑州大学 2025-01-21 — — CN disclosed
CN-118271261-A Dicarbonyl compound containing cyclobutane segment and synthesis method thereof 中国科学技术大学 2024-07-02 — — CN disclosed
US-20240149237-A1 ACETOACETYL POLYMER - BASED MICROCAPSULES FIRMENICH SA (CH) 2024-05-09 — — US disclosed
US-20240059657-A1 OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS OrsoBio Inc. 2024-02-22 — — US disclosed
CN-114394967-B Method for synthesizing pyrazoloquinoline derivative from 2-pyrazolyl aniline and 1, 3-dicarbonyl compound 宁夏农林科学院农业资源与环境研究所（宁夏土壤与植物营养重点实验室） 2023-12-15 — — CN disclosed
US-11840513-B2 Substituted nicotinimide inhibitors of BTK for treating cancer Guangzhou Innocare Pharma Tech Co., Ltd (CN) 2023-12-12 — — US disclosed
US-4728647-A Amides derived from quinoline, and anxiolytic compositions containing them RHONE-POULENC SANTE (FR) 1988-03-01 — — US disclosed
US-4714492-A HYBRIDIZATION AGENTS ROHM AND HAAS COMPANY (US) 1987-12-22 — — US disclosed
EP-0103486-B1 SMOKING COMPOSITIONS PHILIP MORRIS INCORPORATED (US) 1986-11-20 — — EP disclosed
US-4547568-A RELEASING FLAVOR UPON SMOKING PHILIP MORRIS INCORPORATED (US) 1985-10-15 — — US disclosed
US-4481956-A B-KETOCARBOXYLIC ACID ESTER OF CARBOHYDRATE OF ALGOLHOL PHILIP MORRIS INCORPORATED (US) 1984-11-13 — — US disclosed
EP-0103486-A1 Smoking compositions PHILIP MORRIS INCORPORATED (US) 1984-03-21 — — EP disclosed
US-4179294-A POLYMER MORDANT, ACIDIC PYRAZOLONE-CONTAINING OXONOL DYE, READILY DECOLORIZED BY IMMOBILIZATION FUJI PHOTO FILM CO., LTD. (JP) 1979-12-18 — — US disclosed
US-3993437-A Process for the dyeing of polyamide fibers with sulphur dyestuffs CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) 1976-11-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12378200-B2 Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors ALDH7A1, ACMSD, AMD1 KMT2A 1309/4885NPC1 2098/4885RAB9A 2176/4885
US-20030225153-A1 Process for preparing arylaminopropanols AHR, CYP1A1, CYP1A2 KMT2A 746/4885NPC1 2343/4885RAB9A 3297/4885
US-20240059657-A1 OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS ALDH7A1, ACMSD, AMD1 KMT2A 1309/4885NPC1 2098/4885RAB9A 2176/4885
US-20080262247-A1 Process for preparing arylaminopropanols CYP1A1, CYP1A2, AHR KMT2A 1021/4885NPC1 1631/4885RAB9A 3050/4885
US-11840513-B2 Substituted nicotinimide inhibitors of BTK for treating cancer BTK, SYK, LYN KMT2A 1524/4885NPC1 3638/4885RAB9A 2872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.