Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | AKT1 | P31749 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | PRKCG | P05129 | 1/20 | 0.65 |
| ▸ | PRKCB | P05771 | 1/20 | 0.65 |
| ▸ | PRKCA | P17252 | 1/20 | 0.65 |
| ▸ | PRKCH | P24723 | 1/20 | 0.65 |
| ▸ | PRKCI | P41743 | 1/20 | 0.65 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.65 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.65 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.65 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.65 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | GMNN | O75496 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8874191 | 0.91 | MAPK1 (0.54) | SMN1; SMN2AKT1LMNAPRKD3PRKCG | |
| SCHEMBL878627 | 0.90 | SMN1; SMN2 (0.53) | SMN1; SMN2AKT1LMNAPRKD3PRKCG | |
| SCHEMBL243890 | 0.87 | ADRA1D (0.69) | SMN1; SMN2AKT1LMNAPRKD3PRKCG | |
| SCHEMBL1127893 | 0.87 | ADRA1D (0.69) | SMN1; SMN2AKT1LMNAPRKD3PRKCG | |
| SCHEMBL4371353 | 0.86 | LMNA (0.64) | SMN1; SMN2AKT1LMNAPRKD3PRKCG | |
| SCHEMBL2525610 | 0.86 | LMNA (0.64) | SMN1; SMN2AKT1LMNAPRKD3PRKCG | |
| SCHEMBL10645725 | 0.86 | LMNA (0.64) | SMN1; SMN2AKT1LMNAPRKD3PRKCG | |
| SCHEMBL4804148 | 0.84 | SMN1; SMN2 (0.64) | SMN1; SMN2AKT1LMNAPRKD3PRKCG | |
| SCHEMBL2522867 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2AKT1LMNAPRKD3PRKCG | |
| SCHEMBL1856364 | 0.82 | LMNA (0.51) | SMN1; SMN2AKT1LMNAPRKD3PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841910-A4 | INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2006-09-13 | — | — | EP | disclosed |
| US-6451785-B1 | SUBSTITUTED 3-(TRIPHENYLMETHYLAMINO)AZETIDIN-2-ONE; COA-INDEPENDENT TRANSACYLASE (COA-IT) INHIBITOR; COADMINISTERED WITH EDELFOSINE (ET-18-OCH3) OR OTHER ALKYL-LYSOPHOSPHOLIPID ANALOG | SMITHKLINE BEECHAM CORPORATION | 2002-09-17 | — | — | US | disclosed |
| US-20020082250-A1 | BETA LACTAMS AS ANTIPROLIFERATIVE AGENTS | WAKE FOREST UNIVERSITY HEALTH SCIENCES | 2002-06-27 | — | — | US | disclosed |
| EP-0982991-A1 | BETA LACTAMS AS ANTIPROLIFERATIVE AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998049897-A1 | BETA LACTAMS AS ANTIPROLIFERATIVE AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |
| EP-0841910-A1 | INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997004765-A1 | INHIBITION OF CoA-INDEPENDENT TRANSACYLASE AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020082250-A1 | BETA LACTAMS AS ANTIPROLIFERATIVE AGENTS | COASY, LYPLA1, ACAT1 | SMN1; SMN2 1848/4885AKT1 228/4885LMNA 1542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.