Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7629259 | 0.88 | MEN1 (0.51) | MEN1KMT2AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL15415994 | 0.79 | PBRM1 (0.52) | MEN1KMT2AALDH1A1CYP3A4TSHR | |
| SCHEMBL29557960 | 0.79 | PBRM1 (0.52) | MEN1KMT2AALDH1A1CYP3A4TSHR | |
| SCHEMBL27148809 | 0.79 | SLC22A6 (0.50) | MEN1KMT2AALDH1A1CYP3A4ATM | |
| SCHEMBL29336670 | 0.78 | HTR6 (0.52) | MEN1KMT2AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL28939777 | 0.77 | SLC22A6 (0.49) | MEN1KMT2AALDH1A1CYP3A4ATM | |
| SCHEMBL5729731 | 0.77 | POLB (0.52) | MEN1KMT2AHTR2ASMN1; SMN2HTT | |
| Dimethylformamide SCHEMBL27597593 | 0.77 | SLC22A6 (0.46) | MEN1KMT2AALDH1A1KDM4ECYP3A4 | |
| SCHEMBL3224553 | 0.77 | MPO (0.49) | MEN1KMT2AKDM4ETSHRHTR1A | |
| SCHEMBL29336472 | 0.77 | NAMPT (0.45) | MEN1KMT2AALDH1A1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102791688-B | Estrogen receptor ligands | KAROBIO AB | 2014-11-12 | — | — | CN | claimed |
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-07-18 | — | — | US | disclosed |
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-07-18 | — | — | US | disclosed |
| EP-1501826-B1 | SUBSTITUTED INDOLES AS ALPHA-1 AGONISTS | HOFFMANN LA ROCHE (CH) | 2006-09-27 | — | — | EP | disclosed |
| US-6852726-B2 | Substituted indoles as alpha-1 agonists | SYNTEX LLC (US) | 2005-02-08 | — | — | US | disclosed |
| EP-1501826-A2 | SUBSTITUTED INDOLES AS ALPHA-1 AGONISTS | F. Hoffman-la Roche AG (CH) | 2005-02-02 | — | — | EP | disclosed |
| US-6800623-B2 | A 1,3-DITHIA-4-AZA-ACENAPHTHYLENE 3,3-DIOXIDE COMPOUNDS; TREATING PSYCHOLOGICAL DISORDERS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-10-05 | — | — | US | disclosed |
| US-20030220319-A1 | Substituted indoles as alpha-1 agonists | SYNTEX (U.S.A.) LLC | 2003-11-27 | — | — | US | disclosed |
| US-20030158183-A1 | Method of treating schizophrenia | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-08-21 | — | — | US | disclosed |
| US-20030158181-A1 | Method for treating cerebral ishaemia | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-08-21 | — | — | US | disclosed |
| WO-2003064387-A2 | SUBSTITUTED INDOLES AS ALPHA-1 AGONISTS | F. HOFFMAN-LA ROCHE AG (CH) | 2003-08-07 | — | — | WO | disclosed |
| US-6525045-B2 | 4,5-dihydro-1,3-dithia-4-aza-acenaphthylene-3,3-dioxide compounds for example; treating ischemia, Alzheimer's disease, schizophrenia; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-02-25 | — | — | US | disclosed |
| US-20020013313-A1 | 4,5-dihydro-1,3-dithia-4-aza-acenaphthylene-3,3-dioxide compounds for example; treating ischemia, Alzheimer's disease, schizophrenia; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2002-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158183-A1 | Method of treating schizophrenia | GRIN2A, GRIN1, CHAT | MEN1 4216/4885KMT2A 2721/4885ALDH1A1 998/4885 |
| US-20020013313-A1 | 4,5-dihydro-1,3-dithia-4-aza-acenaphthylene-3,3-dioxide compounds for example; treating ischemia, Alzheimer's disease, schizophrenia; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) | GRIA4, GRIN1, GRIN3A | MEN1 4858/4885KMT2A 1321/4885ALDH1A1 236/4885 |
| US-20030220319-A1 | Substituted indoles as alpha-1 agonists | ADRA1A, ADRB1, ADRA1B | MEN1 3962/4885KMT2A 3486/4885ALDH1A1 475/4885 |
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | NRAS, BRAF, KRAS | MEN1 2257/4885KMT2A 2665/4885ALDH1A1 1786/4885 |
| US-20030158181-A1 | Method for treating cerebral ishaemia | PYGB, DCX, INA | MEN1 1044/4885KMT2A 2763/4885ALDH1A1 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.