SCHEMBL5743318

SCHEMBL5743318

O=C(O)CN(Cc1cccc(F)c1)S(=O)(=O)C1(c2cccc3c2oc2ccccc23)C=CC(c2ccccc2)C=C1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 1/20 0.37
TAS2R14 Q9NYV8 3/20 0.36
PER2 O15055 1/20 0.35
CRY1 Q16526 1/20 0.35
CRY2 Q49AN0 1/20 0.35
DAGLA Q9Y4D2 2/20 0.33
NPSR1 Q6W5P4 2/20 0.32
TSHR P16473 1/20 0.32
PPARG P37231 1/20 0.32
NCOA2 Q15596 1/20 0.32
NCOA1 Q15788 1/20 0.32
NCOA3 Q9Y6Q9 1/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
ALOX5 P09917 1/20 0.32
MAPT P10636 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30
POLB P06746 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5743846 0.85 TAS2R14 (0.36) KEAP1TAS2R14PER2CRY1CRY2
SCHEMBL5743320 0.77 KEAP1 (0.35) KEAP1TAS2R14PER2CRY1CRY2
SCHEMBL5740580 0.76 PTPN1 (0.36) KEAP1DAGLANPSR1MEN1KMT2A
SCHEMBL4458190 0.71 TAS2R14 (0.51) KEAP1TAS2R14DAGLAKMT2AALDH1A1
SCHEMBL5743849 0.66 TAS2R14 (0.35) KEAP1TAS2R14PER2CRY1CRY2
SCHEMBL4267916 0.65 ECE1 (0.37) PPARGMEN1KMT2AALDH1A1
SCHEMBL5744955 0.63 MTNR1A (0.35) KEAP1MAPT
SCHEMBL4459383 0.61 KEAP1 (0.48) KEAP1DAGLANPSR1ALDH1A1
SCHEMBL5742273 0.58 PTPN1 (0.39)
SCHEMBL18224013 0.57 ALDH1A1 (0.47) KEAP1TAS2R14DAGLAKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2006525365-A 2006-11-09 JP claimed
EP-1620422-A2 PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B The Institutes for Pharmaceutical Discovery, LLC (US) 2006-02-01 EP claimed
WO-2004099170-A2 PHENYL SUBSTITUTED CARBOXYLIC ACIDS AS INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE-1B THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) 2004-11-18 WO claimed