Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.37 |
| ▸ | RGS4 | P49798 | 1/20 | 0.37 |
| ▸ | RGS8 | P57771 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764324 | 0.86 | ALDH1A1 (0.47) | ALDH1A1HSD17B10HPGDMAPTHTR6 | |
| SCHEMBL5762802 | 0.86 | ALDH1A1 (0.47) | ALDH1A1HSD17B10TP53HPGDMAPT | |
| SCHEMBL5764673 | 0.79 | LMNA (0.37) | TP53MAPTABHD6HTTTSHR | |
| SCHEMBL5764583 | 0.73 | ALDH1A1 (0.36) | ALDH1A1HSD17B10HPGDNPBWR1MAPT | |
| SCHEMBL5764846 | 0.71 | GPR4 (0.44) | ALDH1A1HPGDMAPTHTTKDM4E | |
| SCHEMBL5765021 | 0.68 | GAA (0.38) | ALDH1A1HSD17B10HPGDMAPTHTR6 | |
| SCHEMBL5764178 | 0.66 | MAPT (0.40) | ALDH1A1HSD17B10TP53MAPTHTR6 | |
| SCHEMBL5764508 | 0.65 | PPARG (0.40) | ALDH1A1HSD17B10HPGDMAPTKDM4E | |
| SCHEMBL46757 | 0.64 | HTR2A (0.63) | ALDH1A1MAPTKDM4EGAATSHR | |
| SCHEMBL4083104 | 0.63 | TP53 (0.54) | ALDH1A1TP53MAPTHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091738-B1 | BICYCLIC sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2006-12-06 | — | — | EP | disclosed |
| US-6384041-B1 | ANTIINFLAMMATORY AGENT, TREATMENT OF SHOCK AND ENZYME INHIBITORS | ELI LILLY AND COMPANY | 2002-05-07 | — | — | US | disclosed |