Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 4/20 | 0.33 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5762802 | 0.85 | ALDH1A1 (0.47) | ALDH1A1HSD17B10TSHRNPSR1MAPT | |
| SCHEMBL5764971 | 0.79 | PLA2G1B (0.40) | ALDH1A1MAPTPOLBPLA2G2A | |
| SCHEMBL5764442 | 0.77 | HPGD (0.44) | ALDH1A1HSD17B10KDM4ETSHRNPSR1 | |
| SCHEMBL5764324 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4ETSHRNPSR1 | |
| SCHEMBL5764441 | 0.73 | ALDH1A1 (0.39) | ALDH1A1HSD17B10KDM4ETSHRNPSR1 | |
| SCHEMBL5764846 | 0.70 | GPR4 (0.44) | ALDH1A1KDM4ETSHRNPSR1MAPT | |
| SCHEMBL2156481 | 0.67 | PLA2G2A (0.42) | ALDH1A1HSD17B10KDM4ETSHRMAPT | |
| SCHEMBL2156559 | 0.65 | MTNR1B (0.49) | KDM4ETSHRNPSR1HTR7PLA2G2A | |
| SCHEMBL5764508 | 0.65 | PPARG (0.40) | ALDH1A1HSD17B10KDM4ETSHRNPSR1 | |
| SCHEMBL3196495 | 0.65 | PLA2G2A (0.40) | HSD17B10MAPTPLA2G2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091738-B1 | BICYCLIC sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2006-12-06 | — | — | EP | disclosed |
| US-6384041-B1 | ANTIINFLAMMATORY AGENT, TREATMENT OF SHOCK AND ENZYME INHIBITORS | ELI LILLY AND COMPANY | 2002-05-07 | — | — | US | disclosed |