Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | PTPRF | P10586 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373022 | 0.80 | ADH1B (0.42) | MEN1KMT2ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL7061205 | 0.77 | RAB9A (0.40) | LMNASMN1; SMN2GAAHTTRAB9A | |
| SCHEMBL9058794 | 0.76 | CRHBP (0.46) | CHRM2IDO1LOXL2 | |
| SCHEMBL445466 | 0.74 | KCNH2 (0.48) | IDO1LOXL2 | |
| SCHEMBL7064438 | 0.70 | CYP1A2 (0.49) | CHRM2MEN1KMT2ALMNAMAPT | |
| SCHEMBL3390506 | 0.70 | CHRM2 (0.50) | CHRM2PTPRFPTPN2PTPN1PTPN11 | |
| SCHEMBL628651 | 0.70 | CHRM2 (0.72) | CHRM2PTPRFPTPN2PTPN1PTPN11 | |
| SCHEMBL9871561 | 0.70 | CHRM2 (0.53) | CHRM2PTPRFPTPN2PTPN1PTPN11 | |
| SCHEMBL14128576 | 0.69 | CHRM2 (0.49) | CHRM2PTPRFPTPN2PTPN1PTPN11 | |
| SCHEMBL9969496 | 0.68 | CHRM2 (0.64) | CHRM2PTPRFPTPN2PTPN1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244660-B1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| US-20030181449-A1 | Methods and compositions for the treatment of pain | ASTRAZENCA AB (SE) | 2003-09-25 | — | — | US | disclosed |
| EP-1244660-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001047924-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2001-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181449-A1 | Methods and compositions for the treatment of pain | OPRK1, ACHE, OPRD1 | CHRM2 69/4885PTPRF 3203/4885PTPN2 4086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.