Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776587 | 0.88 | LMNA (0.40) | LMNASMN1; SMN2NPC1TP53HTT | |
| SCHEMBL5773717 | 0.86 | L3MBTL1 (0.52) | LMNANPC1RAB9AHPGDTSHR | |
| SCHEMBL5772132 | 0.85 | LMNA (0.54) | LMNASMN1; SMN2RAB9AHPGDUSP2 | |
| SCHEMBL5774005 | 0.85 | LMNA (0.37) | LMNASMN1; SMN2NPC1TP53HTT | |
| Trifluoroacetic Acid SCHEMBL5774893 | 0.83 | GAA (0.47) | LMNASMN1; SMN2NPC1TP53HTT | |
| SCHEMBL5773900 | 0.83 | CYP1A2 (0.52) | SMN1; SMN2NPC1RAB9AHPGDKDM4E | |
| SCHEMBL5773415 | 0.83 | MTNR1A (0.38) | LMNASMN1; SMN2TP53HPGDUSP2 | |
| SCHEMBL5774669 | 0.82 | HPGD (0.37) | LMNASMN1; SMN2NPC1TP53HTT | |
| SCHEMBL5774227 | 0.82 | ALDH1A1 (0.38) | LMNASMN1; SMN2NPC1TP53HTT | |
| SCHEMBL5769962 | 0.81 | SMN1; SMN2 (0.41) | LMNASMN1; SMN2NPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | LMNA 2770/4885SMN1; SMN2 3383/4885NPC1 2417/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | LMNA 2605/4885SMN1; SMN2 2449/4885NPC1 1770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.