Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 13/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 13/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 13/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 13/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 13/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 13/20 | 0.41 |
| ▸ | FAAH | O00519 | 6/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772079 | 0.80 | FAAH (0.47) | FAAHCES1 | |
| SCHEMBL3870461 | 0.66 | MMP1 (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5955874 | 0.66 | CES1 (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4066120 | 0.64 | CTSL (0.37) | — | |
| SCHEMBL4949819 | 0.63 | CTSA (0.38) | — | |
| SCHEMBL3869379 | 0.62 | CTSC (0.46) | — | |
| SCHEMBL363265 | 0.60 | KDM4E (0.45) | — | |
| Hydrochloric Acid SCHEMBL27491870 | 0.59 | KDM4E (0.44) | — | |
| Hydrochloric Acid SCHEMBL28047477 | 0.59 | KDM4E (0.44) | — | |
| SCHEMBL6206827 | 0.59 | CES1 (0.53) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682524-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005040142-A9 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | AVENTIS PHARMA INC (US) | 2005-06-09 | — | — | WO | claimed |
| WO-2005040142-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-06 | — | — | WO | claimed |
| EP-1682524-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005040142-A9 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | AVENTIS PHARMA INC (US) | 2005-06-09 | — | — | WO | disclosed |
| WO-2005040142-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-06 | — | — | WO | disclosed |