Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 3/20 | 0.32 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA9 | Q16790 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CA3 | P07451 | 2/20 | 0.32 |
| ▸ | CA4 | P22748 | 2/20 | 0.32 |
| ▸ | CA6 | P23280 | 2/20 | 0.32 |
| ▸ | CA5A | P35218 | 2/20 | 0.32 |
| ▸ | CA7 | P43166 | 2/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzo[D]Isoxazole SCHEMBL5773958 | 0.91 | TDP1 (0.34) | TDP1ALDH1A1HSD17B10CA2NPC1 | |
| Benzo[D]Isoxazole SCHEMBL5778868 | 0.88 | TDO2 (0.34) | TDP1ALDH1A1HSD17B10CA2NPC1 | |
| Benzo[D]Isoxazole SCHEMBL1355530 | 0.85 | — | — | |
| Benzo[D]Isoxazole SCHEMBL8438 | 0.85 | — | — | |
| Benzo[D]Isoxazole SCHEMBL29366929 | 0.85 | — | — | |
| Benzo[D]Isoxazole SCHEMBL27515218 | 0.84 | CA12 (0.35) | TDP1CA2NPC1RAB9ACA12 | |
| Benzo[D]Isoxazole SCHEMBL1982876 | 0.83 | TDO2 (0.34) | TDP1ALDH1A1HSD17B10CA2NPC1 | |
| Benzo[D]Isoxazole SCHEMBL29184280 | 0.83 | TDO2 (0.34) | TDP1ALDH1A1HSD17B10CA2NPC1 | |
| Benzo[D]Isoxazole SCHEMBL21596877 | 0.83 | TDO2 (0.34) | TDP1ALDH1A1HSD17B10CA2NPC1 | |
| Benzo[D]Isoxazole SCHEMBL5158032 | 0.83 | TDO2 (0.34) | TDP1ALDH1A1HSD17B10CA2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936720-B2 | Method for preparing benzisoxazole methane sulfonyl chloride and its amidation to form zonisamide | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2005-08-30 | — | — | US | claimed |
| US-20060084814-A1 | Process for the preparation of zonisamide | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2006-04-20 | — | — | US | disclosed |
| EP-1472236-A4 | METHOD FOR PREPARING BENZISOXAZOLE METHANE SULFONYL CHLORIDE AND ITS AMIDATION TO FORM ZONISAMIDE | TEVA PHARMA (IL) | 2006-04-19 | — | — | EP | disclosed |
| US-20060069267-A1 | Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | NIDAM TAMAR | 2006-03-30 | — | — | US | disclosed |
| US-20060063936-A1 | Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | NIDAM TAMAR | 2006-03-23 | — | — | US | disclosed |
| US-7015330-B2 | Sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-03-21 | — | — | US | disclosed |
| US-6936720-B2 | Method for preparing benzisoxazole methane sulfonyl chloride and its amidation to form zonisamide | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2005-08-30 | — | — | US | disclosed |
| US-6936720-B2 | Method for preparing benzisoxazole methane sulfonyl chloride and its amidation to form zonisamide | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2005-08-30 | — | — | US | disclosed |
| CN-1636002-A | Method for preparing benzisoxazole methylsulfonyl chloride and amidating it to form zonisamide | TEVA PHARMA (IL) | 2005-07-06 | — | — | CN | disclosed |
| US-20050027126-A1 | Processes for preparing zonisamide intermediates and novel crystalline forms of zonisamide intermediates | NIDAM TAMAR (IL) | 2005-02-03 | — | — | US | disclosed |
| US-20040138471-A1 | Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | MENDELOVICI MARIOARA (IL) | 2004-07-15 | — | — | US | disclosed |
| US-20040138472-A1 | Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | MENDELOVICI MARIOARA | 2004-07-15 | — | — | US | disclosed |
| EP-1430037-A1 | ZONISAMIDE INTERMEDIATE AND SYNTHESIS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-06-23 | — | — | EP | disclosed |
| WO-2004020419-A1 | NOVEL SULFONATION METHOD FOR ZONISAMIDE INTERMEDIATE IN ZONISAMIDE SYNTHESIS AND THEIR NOVEL CRYSTAL FORMS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2004-03-11 | — | — | WO | disclosed |
| US-20040014983-A1 | Method for preparing benzisoxazole methane sulfonyl chloride and its amidation to form zonisamide | TEVA PHARMACEUTICALS USA INC. | 2004-01-22 | — | — | US | disclosed |
| US-20040014983-A1 | Method for preparing benzisoxazole methane sulfonyl chloride and its amidation to form zonisamide | TEVA PHARMACEUTICALS USA INC. | 2004-01-22 | — | — | US | disclosed |
| WO-2003072552-A1 | METHOD FOR PREPARING BENZISOXAZOLE METHANE SULFONYL CHLORIDE AND ITS AMIDATION TO FORM ZONISAMIDE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2003-09-04 | — | — | WO | disclosed |
| US-20030144527-A1 | Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | TEVA PHARMACEUTICALS USA, INC. | 2003-07-31 | — | — | US | disclosed |
| US-20030114682-A1 | Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2003-06-19 | — | — | US | disclosed |
| WO-2003020708-A1 | ZONISAMIDE INTERMEDIATE AND SYNTHESIS | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2003-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138471-A1 | Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | CA3, ARSA, CBS | TDP1 4808/4885ALDH1A1 1574/4885HSD17B10 934/4885 |
| US-20040138472-A1 | Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | CA3, ARSA, CBS | TDP1 4808/4885ALDH1A1 1574/4885HSD17B10 934/4885 |
| US-20060084814-A1 | Process for the preparation of zonisamide | CYP3A43, CYP3A4, CYP3A5 | TDP1 4729/4885ALDH1A1 1122/4885HSD17B10 797/4885 |
| US-20030114682-A1 | Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | CA3, ARSA, CBS | TDP1 4808/4885ALDH1A1 1574/4885HSD17B10 934/4885 |
| US-20060069267-A1 | Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | CA3, ARSA, CBS | TDP1 4808/4885ALDH1A1 1574/4885HSD17B10 934/4885 |
| US-20050027126-A1 | Processes for preparing zonisamide intermediates and novel crystalline forms of zonisamide intermediates | CA3, BCHE, CA1 | TDP1 4786/4885ALDH1A1 2016/4885HSD17B10 1318/4885 |
| US-20030144527-A1 | Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | ARSA, BCHE, CA3 | TDP1 4780/4885ALDH1A1 994/4885HSD17B10 694/4885 |
| US-20040014983-A1 | Method for preparing benzisoxazole methane sulfonyl chloride and its amidation to form zonisamide | GABRA2, GABRA5, GABRA4 | TDP1 4860/4885ALDH1A1 3916/4885HSD17B10 4090/4885 |
| US-20060063936-A1 | Novel sulfonation method for zonisamide intermediate in zonisamide synthesis and their novel crystal forms | CA3, ARSA, CBS | TDP1 4808/4885ALDH1A1 1574/4885HSD17B10 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.