Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MEP1B | Q16820 | 5/20 | 0.38 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5779568 | 0.90 | BCHE (0.43) | HSD17B1HSD17B2MEP1BMEP1APPARG | |
| SCHEMBL5779117 | 0.81 | MEP1B (0.41) | NOS1KMT2AMEN1MEP1BPPARG | |
| SCHEMBL5489563 | 0.79 | HPGD (0.45) | ALDH1A1 | |
| SCHEMBL5777797 | 0.79 | PBRM1 (0.42) | ALDH1A1KMT2AMEN1CYP3A4 | |
| SCHEMBL5200753 | 0.79 | PARP1 (0.43) | ALDH1A1TSHRKMT2AMEN1L3MBTL1 | |
| SCHEMBL289811 | 0.78 | EGFR (0.50) | ALDH1A1KMT2A | |
| SCHEMBL5771539 | 0.76 | CES2 (0.50) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL29630981 | 0.75 | FOLH1 (0.59) | ALDH1A1TSHRKMT2AMEN1MEP1B | |
| SCHEMBL168738 | 0.75 | FOLH1 (0.59) | ALDH1A1TSHRKMT2AMEN1MEP1B | |
| SCHEMBL3694401 | 0.75 | NOS1 (0.51) | NOS1ALDH1A1TSHRROCK2HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648875-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |