Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 8/20 | 0.42 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776042 | 0.90 | NOS1 (0.42) | MEP1BMEP1APPARGCYP2C19HSD17B1 | |
| SCHEMBL5200753 | 0.79 | PARP1 (0.43) | CYP1A2CYP2C19 | |
| SCHEMBL5779117 | 0.78 | MEP1B (0.41) | BCHEMEP1BPPARGHDAC8HDAC6 | |
| SCHEMBL5489563 | 0.76 | HPGD (0.45) | — | |
| SCHEMBL5777797 | 0.76 | PBRM1 (0.42) | — | |
| SCHEMBL289811 | 0.74 | EGFR (0.50) | — | |
| SCHEMBL5915679 | 0.73 | POLB (0.57) | BCHEMEP1BMEP1AAOC3PPARG | |
| SCHEMBL4407864 | 0.73 | MEP1B (0.65) | BCHEMEP1BMEP1APTPN1LTA4H | |
| SCHEMBL5771539 | 0.72 | CES2 (0.50) | — | |
| SCHEMBL26686942 | 0.72 | TSHR (0.52) | BCHEAOC3CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648875-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |