Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5489563 | 0.81 | HPGD (0.45) | POLBALDH1A1KDM4EGAA | |
| SCHEMBL5200753 | 0.81 | PARP1 (0.43) | NPC1LMNAPOLBALDH1A1KDM4E | |
| SCHEMBL5776042 | 0.79 | NOS1 (0.42) | ALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL289811 | 0.79 | EGFR (0.50) | NPC1ALDH1A1KDM4EEGFRRAB9A | |
| SCHEMBL5771539 | 0.77 | CES2 (0.50) | LMNAPOLBALDH1A1OPRM1PTGS1 | |
| SCHEMBL5796510 | 0.77 | MAPT (0.56) | NPC1LMNAPOLBALDH1A1GAA | |
| SCHEMBL5779568 | 0.76 | BCHE (0.43) | — | |
| SCHEMBL5779117 | 0.74 | MEP1B (0.41) | MEN1KMT2ASMN1; SMN2HIF1A | |
| SCHEMBL847542 | 0.71 | ALDH1A1 (0.44) | LMNAALDH1A1KDM4EOPRM1OPRD1 | |
| SCHEMBL5185723 | 0.69 | MAOA (0.41) | NPC1LMNAALDH1A1KDM4EOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648875-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |