Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557772 | 0.88 | MEN1 (0.57) | PPARGPTGS2ALOX5PARP1MEN1 | |
| SCHEMBL5881838 | 0.79 | MEN1 (0.51) | PPARGMEN1KMT2AATML3MBTL1 | |
| SCHEMBL251645 | 0.76 | ALOX5 (0.43) | PPARGALOX5ALDH1A1NPC1NR4A2 | |
| SCHEMBL8555747 | 0.76 | PLK1 (0.39) | PPARGALOX5MCL1 | |
| SCHEMBL5881790 | 0.74 | PTPN5 (0.58) | PPARGPTGS2ALOX5MEN1KMT2A | |
| SCHEMBL8556812 | 0.74 | ROCK2 (0.60) | L3MBTL1TP53KDM4EROCK2ALDH1A1 | |
| SCHEMBL8554376 | 0.73 | ROCK2 (0.56) | L3MBTL1TP53KDM4EROCK2MAPT | |
| SCHEMBL7424550 | 0.73 | ALOX5 (0.39) | ALOX5MEN1KMT2AALDH1A1GAA | |
| SCHEMBL11094349 | 0.72 | ALDH1A1 (0.53) | PPARGMEN1KMT2ATP53KDM4E | |
| SCHEMBL27483791 | 0.72 | KDM4E (0.46) | PPARGPARP1MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1624893-A2 | INHIBITORS OF PHOSPHODIESTERASES IN INFERTILITY | Applied Research Systems ARS Holding N.V. (AN) | 2006-02-15 | — | — | EP | claimed |
| WO-2004087211-A2 | INHIBITORS OF PHOSPHODIESTERASES IN INFERTILITY | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-10-14 | — | — | WO | claimed |
| EP-1673355-A1 | SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS | Pfizer Limited (GB) | 2006-06-28 | — | — | EP | disclosed |
| EP-1562602-A2 | IMMEDIATE RELEASE TOPICAL PHARMACEUTICAL FORMULATION FOR ENHANCEMENT OF FEMALE SEXUAL DESIRE AND RESPONSIVENESS | Vivus, Inc. (US) | 2005-08-17 | — | — | EP | disclosed |
| WO-2005028452-A1 | SUBSTITUTED TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS | PFIZER LIMITED (GB) | 2005-03-31 | — | — | WO | disclosed |
| WO-2004037262-A2 | IMMEDIATE RELEASE TOPICAL PHARMACEUTICAL FORMULATION FOR ENHANCEMENT OF FEMALE SEXUAL DESIRE AND RESPONSIVENESS | VIVUS, INC. (US) | 2004-05-06 | — | — | WO | disclosed |