Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.33 |
| ▸ | S100A10 | P60903 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA4 | P22748 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | HTR3A | P46098 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5849481 | 0.92 | TDP1 (0.39) | MAPTKDM4ENSD2MAPK1MMP13 | |
| Trifluoromethanesulfonic Acid SCHEMBL5850147 | 0.85 | PTGS1 (0.39) | MAPTKDM4ENSD2MAPK1SIRT1 | |
| SCHEMBL298034 | 0.85 | SIRT1 (0.40) | MAPTKDM4ENSD2MAPK1SIRT1 | |
| SCHEMBL5849477 | 0.84 | L3MBTL1 (0.35) | MAPTKDM4ENSD2MAPK1SIRT1 | |
| Hydrochloric Acid SCHEMBL8980364 | 0.84 | SIRT1 (0.39) | MAPTKDM4ENSD2MAPK1SIRT1 | |
| SCHEMBL2634898 | 0.82 | KCNH2 (0.43) | CA2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL3201612 | 0.82 | SIRT1 (0.40) | MAPTKDM4ENSD2MAPK1SIRT1 | |
| SCHEMBL2903354 | 0.81 | MMP13 (0.44) | MAPTMMP8MMP13MMP3ANXA2 | |
| SCHEMBL29848318 | 0.79 | SIRT1 (0.36) | MAPTKDM4ENSD2MAPK1SIRT1 | |
| SCHEMBL5849960 | 0.79 | PTGS1 (0.32) | MAPTKDM4ENSD2MAPK1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984473-B2 | Light blocking; amplified photoresist; acid generators; high density semiconductors | MITSUBISHI DENKI KABUSHIKI KAISHA (JP) | 2006-01-10 | — | — | US | disclosed |
| US-20030152845-A1 | Mask blank, protective film therefor and method of patterning mask blank | MITSUBISHI DENKI KABUSHIKI KAISHA (JP) | 2003-08-14 | — | — | US | disclosed |