Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.72 |
| ▸ | TSHR | P16473 | 3/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26790702 | 0.89 | ALDH1A1 (0.60) | ALDH1A1TSHRMAPK1GRIN2DGRIN3B | |
| SCHEMBL954217 | 0.84 | ALDH1A1 (1.00) | ALDH1A1TSHRMAPK1GRIN2DGRIN3B | |
| SCHEMBL16039290 | 0.80 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPK1GRIN2DGRIN3B | |
| SCHEMBL14247122 | 0.80 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPK1GRIN2DGRIN3B | |
| SCHEMBL16319820 | 0.80 | ALDH1A1 (0.50) | ALDH1A1TSHRMAPK1GRIN2DGRIN3B | |
| SCHEMBL2645579 | 0.79 | ALDH1A1 (0.72) | ALDH1A1TSHRMAPK1GRIN2DGRIN3B | |
| SCHEMBL30038307 | 0.77 | TSHR (0.53) | ALDH1A1TSHRMAPK1MAPTHTT | |
| SCHEMBL2792876 | 0.77 | TSHR (0.53) | ALDH1A1TSHRMAPK1MAPTHTT | |
| SCHEMBL8066632 | 0.77 | ALDH1A1 (0.75) | ALDH1A1TSHRMAPK1GRIN2DGRIN3B | |
| SCHEMBL14247077 | 0.76 | VCAM1 (0.51) | ALDH1A1TSHRGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10751335-B2 | Signaling-biased mu opioid receptor agonists | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-08-25 | — | — | US | disclosed |
| US-20190055214-A1 | SIGNALING-BIASED MU OPIOID RECEPTOR AGONISTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2019-02-21 | — | — | US | disclosed |
| EP-3430007-A1 | SIGNALING-BIASED MU OPIOID RECEPTOR AGONISTS | The Scripps Research Institute (US) | 2019-01-23 | — | — | EP | disclosed |
| WO-2017161017-A1 | SIGNALING-BIASED MU OPIOID RECEPTOR AGONISTS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-09-21 | — | — | WO | disclosed |
| US-7098338-B2 | 2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a) quinoxalin-5(6H)one derivatives | WYETH (US) | 2006-08-29 | — | — | US | disclosed |
| US-20040116437-A1 | 2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a) quinoxalin-5(6H)one derivatives | WYETH (US) | 2004-06-17 | — | — | US | disclosed |
| US-6706714-B2 | USEFUL FOR THE TREATMENT OF DISORDERS INVOLVING THE CENTRAL NERVOUS SYSTEM SUCH AS OBSESSIVE-COMPULSIVE DISORDER, DEPRESSION, ANXIETY, SCHIZOPHERNIA, MIGRAINE, SLEEP OR EATING DISORDER, OBESITY, TYPE II DIABETES AND EPILEPSY | WYETH CORP (US) | 2004-03-16 | — | — | US | disclosed |
| US-20030060468-A1 | 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)one derivatives | WYETH (US) | 2003-03-27 | — | — | US | disclosed |
| US-6476032-B2 | 5HT2C RECEPTOR AGONISTS TO TREAT SCHIZOPHRENIA AND CENTRAL NERVOUS SYSTEM DISORDERS; OBSESSIVE-COMPULSIVE DISORDER; ANTIDEPRESSANTS, MIGRAINE; SLEEP DISORDERS; EATING DISORDERS; OBESITY; ANTIDIABETIC, -EPILEPTIC AND ANXIOLYTIC AGENTS | WYETH | 2002-11-05 | — | — | US | disclosed |
| US-6372745-B1 | TREATMENT OF OBESITY IN MAMMALS | AMERICAN HOME PRODUCTS CORPORATION | 2002-04-16 | — | — | US | disclosed |
| US-20010051622-A1 | 2,3,4,4a-tetrahydro-1H-pyrazino-[1,2a] quinoxalin-5- (6H) one derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-12-13 | — | — | US | disclosed |
| EP-1140940-A1 | 2,3,4,4A-TETRAHYDRO-1H-PYRAZINO(1,2-A)QINOXALIN-5(6H)ONE DERIVATES BEING 5HT2C AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035922-A1 | 2,3,4,4A-TETRAHYDRO-1H-PYRAZINO(1,2-A)QUINOXALIN-5(6H)ONE DERIVATES BEING 5HT2C AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10751335-B2 | Signaling-biased mu opioid receptor agonists | OPRK1, OPRM1, OPRD1 | ALDH1A1 1557/4885TSHR 420/4885MAPK1 235/4885 |
| US-20190055214-A1 | SIGNALING-BIASED MU OPIOID RECEPTOR AGONISTS | OPRK1, OPRM1, OPRD1 | ALDH1A1 1557/4885TSHR 420/4885MAPK1 235/4885 |
| US-20030060468-A1 | 2,3,4,4a-Tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)one derivatives | NPY2R, HCRTR2, HTR2C | ALDH1A1 1969/4885TSHR 134/4885MAPK1 2143/4885 |
| US-20010051622-A1 | 2,3,4,4a-tetrahydro-1H-pyrazino-[1,2a] quinoxalin-5- (6H) one derivatives | HTR2C, HTR3C, NPY2R | ALDH1A1 2135/4885TSHR 143/4885MAPK1 1954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.