SCHEMBL587377

SCHEMBL587377

C#C[SiH2]c1cccc(C)c1C

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.38
ATM Q13315 1/20 0.38
CYP1A2 P05177 1/20 0.33
CYP2A6 P11509 1/20 0.33
TSHR P16473 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
ALDH1A1 P00352 2/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
ACHE P22303 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
KEAP1 Q14145 1/20 0.31
NFE2L2 Q16236 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3947302 0.82 TRPA1 (0.41) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL15363723 0.78 TRPA1 (0.38) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL8993154 0.74 TRPA1 (0.34) TRPA1ATMCYP1A2CYP2A6
SCHEMBL12477034 0.72 TRPA1 (0.33) TRPA1ATM
SCHEMBL4416945 0.72 TRPA1 (0.38) TRPA1ATMTSHRSMN1; SMN2ALDH1A1
SCHEMBL10696455 0.72 TRPA1 (0.44) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL29776862 0.72 TRPA1 (0.44) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL7768863 0.70 TRPA1 (0.42) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL6857979 0.70 TRPA1 (0.42) TRPA1ATMCYP1A2CYP2A6TSHR
SCHEMBL7179945 0.70 TRPA1 (0.42) TRPA1ATMCYP1A2CYP2A6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11814462-B2 Functionalized cyclic polymers and methods of preparing same UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2023-11-14 US claimed
US-20220056167-A1 Functionalized Cyclic Polymers and Methods of Preparing Same NATIONAL SCIENCE FOUNDATION 2022-02-24 US claimed
WO-2020223672-A1 FUNCTIONALIZED CYCLIC POLYMERS AND METHODS OF PREPARING SAME UNIVERSITY OF FLORIDA RESEARCHFOUNDATION, INC. (US) 2020-11-05 WO claimed
US-12404353-B2 Olefin polymerization catalyst, olefin polymerization catalyst production method, and olefin polymer production method using the olefin polymerization catalyst JAPAN POLYPROPYLENE CORPORATION (JP) 2025-09-02 US disclosed
US-20240397815-A1 PHOTOELECTRIC CONVERSION ELEMENT, IMAGING ELEMENT, OPTICAL SENSOR, AND COMPOUND FUJIFILM CORPORATION (JP) 2024-11-28 US disclosed
CN-107955052-B Method for alkynylating 16-substituted-17-ketosteroids 晶体制药独资有限公司 2024-07-05 CN disclosed
CN-115315451-B Catalyst for olefin polymerization, method for producing catalyst for olefin polymerization, and method for producing olefin polymer using catalyst for olefin polymerization 日本聚丙烯株式会社 2023-12-01 CN disclosed
US-11814462-B2 Functionalized cyclic polymers and methods of preparing same UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2023-11-14 US disclosed
WO-2023171788-A1 PHOTOELECTRIC CONVERSION ELEMENT, IMAGING ELEMENT, PHOTOSENSOR, AND COMPOUND 富士フイルム株式会社 2023-09-14 WO disclosed
US-20230142911-A1 OLEFIN POLYMERIZATION CATALYST, OLEFIN POLYMERIZATION CATALYST PRODUCTION METHOD, AND OLEFIN POLYMER PRODUCTION METHOD USING THE OLEFIN POLYMERIZATION CATALYST JAPAN POLYPROPYLENE CORPORATION (JP) 2023-05-11 US disclosed
EP-4105246-A1 CATALYST FOR OLEFIN POLYMERIZATION, PRODUCTION METHOD FOR CATALYST FOR OLEFIN POLYMERIZATION, AND PRODUCTION METHOD FOR OLEFIN POLYMER USING SAID CATALYST FOR OLEFIN POLYMERIZATION Japan Polypropylene Corporation (JP) 2022-12-21 EP disclosed
US-20090069569-A1 CYCLOADDITION OF AZIDES AND ALKYNES INSTITUT CATALA D'INVESTIGACIO QUIMICA (ES) 2009-03-12 US disclosed
US-7495251-B2 Electronic devices containing acene-thiophene copolymers with silylethynyl groups 3M INNOVATIVE PROPERTIES COMPANY (US) 2009-02-24 US disclosed
EP-2010590-A2 ACENE-THIOPHENE COPOLYMERS WITH SILYLETHYNYL GROUPS 3M Innovative Properties Company (US) 2009-01-07 EP disclosed
EP-2011157-A1 ELECTRONIC DEVICES CONTAINING ACENE-THIOPHENE COPOLYMERS WITH SILYLETHYNYL GROUPS 3M Innovative Properties Company (US) 2009-01-07 EP disclosed
WO-2008020774-A1 NEW SILYLSUBSTITUTED 1,2-ALKYNES AND SYNTHESIS OF SILYLSUBSTITUTED 1,2-AIKYNES ADAM MICKIEWICZ UNIVERSITY (PL) 2008-02-21 WO disclosed
WO-2007124266-A2 ACENE-THIOPHENE COPOLYMERS WITH SILYLETHYNYL GROUPS 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-11-01 WO disclosed
WO-2007124286-A1 ELECTRONIC DEVICES CONTAINING ACENE-THIOPHENE COPOLYMERS WITH SILYLETHYNYL GROUPS 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-11-01 WO disclosed
US-20070249802-A1 ACENE-THIOPHENE COPOLYMERS WITH SILETHYNLY GROUPS 3M INNOVATIVE PROPERTIES COMPANY 2007-10-25 US disclosed
US-20070249087-A1 ELECTRONIC DEVICES CONTAINING ACENE-THIOPHENE COPOLYMERS WITH SILYLETHYNYL GROUPS 3M INNOVATIVE PROPERTIES COMPANY 2007-10-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240397815-A1 PHOTOELECTRIC CONVERSION ELEMENT, IMAGING ELEMENT, OPTICAL SENSOR, AND COMPOUND CRY1, PPOX, PIEZO1 TRPA1 177/4885ATM 3147/4885CYP1A2 423/4885
US-20090069569-A1 CYCLOADDITION OF AZIDES AND ALKYNES PF4, AFF4, FLI1 TRPA1 1204/4885ATM 2666/4885CYP1A2 325/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.