Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | GHSR | Q92847 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877465 | 0.92 | LMNA (0.44) | SMN1; SMN2LMNAABCC1MAP3K11CYP2D6 | |
| SCHEMBL5876853 | 0.91 | ABCC1 (0.44) | SMN1; SMN2LMNAABCC1CYP2D6GHSR | |
| SCHEMBL5878313 | 0.91 | PDE4B (0.43) | SMN1; SMN2LMNAABCC1MAP3K11PDE4B | |
| SCHEMBL5878058 | 0.90 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAABCC1CYP2D6POLB | |
| SCHEMBL5877963 | 0.87 | ALDH1A1 (0.47) | SMN1; SMN2LMNAABCC1GHSRPOLB | |
| SCHEMBL5876953 | 0.86 | ABCC1 (0.50) | SMN1; SMN2ABCC1CYP2D6GHSRHTR2C | |
| SCHEMBL5877840 | 0.86 | EGFR (0.45) | SMN1; SMN2LMNAABCC1MAP3K11PDE5A | |
| SCHEMBL5877626 | 0.86 | ABCC1 (0.52) | SMN1; SMN2ABCC1CYP2D6GHSRHTR2C | |
| SCHEMBL5876985 | 0.85 | CRHR1 (0.44) | SMN1; SMN2LMNAABCC1CYP2D6GHSR | |
| SCHEMBL5877811 | 0.85 | ABCC1 (0.46) | ABCC1CYP2D6GHSRHTR2CCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |