SCHEMBL587887

SCHEMBL587887

c1cc2c(cn1)CNCC2

nearest known ligand 0.77

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.77
CHRNA4 P43681 1/20 0.77
PNMT P11086 5/20 0.54
SIGMAR1 Q99720 1/20 0.54
CD44 P16070 1/20 0.54
MAOB P27338 1/20 0.54
ADRA2A P08913 1/20 0.46
ADRA2B P18089 1/20 0.46
ADRA2C P18825 1/20 0.46
PKN2 Q16513 1/20 0.45
DRD2 P14416 1/20 0.43
DRD3 P35462 1/20 0.43
HTR2C P28335 1/20 0.43
ASIC3 Q9UHC3 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29850369 1.00 CHRNB2 (0.77) CHRNB2CHRNA4PNMTSIGMAR1CD44
Hydrochloric Acid SCHEMBL15238605 0.98 CHRNB2 (0.74) CHRNB2CHRNA4PNMTSIGMAR1CD44
Hydrochloric Acid SCHEMBL4790441 0.98 CHRNB2 (0.74) CHRNB2CHRNA4PNMTSIGMAR1CD44
SCHEMBL30183351 0.92 CHRNB2 (0.77) CHRNB2CHRNA4PNMTSIGMAR1CD44
SCHEMBL2565015 0.92 CHRNB2 (0.77) CHRNB2CHRNA4PNMTSIGMAR1CD44
Hydrochloric Acid SCHEMBL785959 0.90 CHRNB2 (0.74) CHRNB2CHRNA4PNMTSIGMAR1CD44
Hydrochloric Acid SCHEMBL29759853 0.90 CHRNB2 (0.74) CHRNB2CHRNA4PNMTSIGMAR1CD44
SCHEMBL19194504 0.88 SIGMAR1 (0.61) CHRNB2CHRNA4PNMTSIGMAR1CD44
SCHEMBL19200207 0.87 CHRNB2 (1.00) CHRNB2CHRNA4PNMTSIGMAR1CD44
Trifluoroacetic Acid SCHEMBL30343298 0.84 CHRNB2 (0.56) CHRNB2CHRNA4PNMTSIGMAR1CD44

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 375 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4658655-A1 CONDENSED HETEROCYCLIC COMPOUNDS AS INHIBITOR OF DIACYLGLYCEROL KINASES Beone Medicines I GmbH (CH) 2025-12-10 EP claimed
US-20250353858-A1 CONDENSED HETEROCYCLIC COMPOUNDS AS INHIBITOR OF DIACYLGLYCEROL KINASES BEONE MEDICINES I GMBH (CH) 2025-11-20 US claimed
CN-111655695-B Substituted furopyrimidine compounds as PDE1 inhibitors 达特神经科学有限公司 2025-05-27 CN claimed
WO-2024160278-A1 CONDENSED HETEROCYCLIC COMPOUNDS AS INHIBITOR OF DIACYLGLYCEROL KINASES BEIGENE, LTD. (KY) 2024-08-08 WO claimed
EP-4408842-A1 BICYCLIC AMINE DERIVATIVES AS GABAA a5 RECEPTOR MODULATORS Richter Gedeon Nyrt. (HU) 2024-08-07 EP claimed
WO-2023053015-A1 BICYCLIC AMINE DERIVATIVES AS GABAA α5 RECEPTOR MODULATORS RICHTER GEDEON NYRT. (HU) 2023-04-06 WO claimed
EP-4126859-A1 NAPHTHYRIDINE AND PYRIDO[3,4-C]PYRIDAZINE DERIVATIVES AS GABAA ALPHA5 RECEPTOR MODULATORS Richter Gedeon Nyrt. (HU) 2023-02-08 EP claimed
WO-2021191838-A1 NAPHTHYRIDINE AND PYRIDO[3,4-c]PYRIDAZINE DERIVATIVES AS GABAA α5 RECEPTOR MODULATORS RICHTER GEDEON NYRT. (HU) 2021-09-30 WO claimed
EP-3717488-A1 SUBSTITUTED FURANOPYRIMIDINE COMPOUNDS AS PDE1 INHIBITORS Dart NeuroScience, LLC (US) 2020-10-07 EP claimed
CN-111655695-A Substituted furopyrimidines as PDE1 inhibitors 达特神经科学有限公司 2020-09-11 CN claimed
WO-2019104285-A1 SUBSTITUTED FURANOPYRIMIDINE COMPOUNDS AS PDE1 INHIBITORS DART NEUROSCIENCE, LLC (US) 2019-05-31 WO claimed
US-20100130495-A1 COMPOUNDS 563 ASTRAZENECA AB (SE) 2010-05-27 US claimed
US-6476226-B2 PLATELET GLYCOPROTEIN IIB/IIIA FIBRINOGEN; ANTICOAGULANTS; THROMBOLYTIC AGENTS; THROMBOEMBOLIC DISORDERS; ANTIINFLAMMATORY AGENTS; BONE DISORDERS; ANTITUMOR, -METASTASIS, -ARTHRITIC AGENTS; ASTHMA; PSORIASIS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-11-05 US claimed
US-20020094978-A1 Novel isoxazoline fibrinogen receptor antagonists BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-07-18 US claimed
US-6303609-B1 USED FOR THE INHIBITION OF PLATELET AGGREGATION, AS THROMBOLYTICS, AND/OR FOR THE TREATMENT OF THROMBOEMBOLIC DISORDERS DUPONT PHARMACEUTICALS COMPANY 2001-10-16 US claimed
EP-1131306-A2 ISOXAZOLINE FIBRINOGEN RECEPTOR ANTAGONISTS Du Pont Pharmaceuticals Company (US) 2001-09-12 EP claimed
WO-2000029406-A2 NOVEL ISOXAZOLINE FIBRINOGEN RECEPTOR ANTAGONISTS DU PONT PHARMACEUTICALS COMPANY (US) 2000-05-25 WO claimed
US-12637461-B2 Compounds for the activation of AMPK PFIZER INC. (US) 2026-05-26 US disclosed
WO-1989005643-A1 HETEROCYCLIC-SUBSTITUTED QUINOLINE-CARBOXYLIC ACIDS PFIZER INC. (US) 1989-06-29 WO disclosed
EP-0321191-A2 Heterocyclic-substituted quinoline-carboxylic acids PFIZER INC. (US) 1989-06-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250353858-A1 CONDENSED HETEROCYCLIC COMPOUNDS AS INHIBITOR OF DIACYLGLYCEROL KINASES DGKG, DGKK, DGKA CHRNB2 4235/4885CHRNA4 4388/4885PNMT 2786/4885
US-12637461-B2 Compounds for the activation of AMPK PRKAG1, PRKAB1, PRKAA1 CHRNB2 1490/4885CHRNA4 1721/4885PNMT 4553/4885
US-20020094978-A1 Novel isoxazoline fibrinogen receptor antagonists F13B, F11, FGB CHRNB2 1795/4885CHRNA4 1227/4885PNMT 4807/4885
US-20100130495-A1 COMPOUNDS 563 BACE1, PSEN1, PSEN2 CHRNB2 43/4885CHRNA4 85/4885PNMT 270/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.