Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 9/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27388451 | 0.78 | CYP11B1 (0.54) | CYP11B1CYP11B2HSP90AA1HSP90AB1IDO1 | |
| SCHEMBL9092542 | 0.78 | CYP11B1 (0.54) | CYP11B1CYP11B2HSP90AA1HSP90AB1IDO1 | |
| Trifluoroacetic Acid SCHEMBL5880541 | 0.77 | CYP11B1 (0.58) | CYP11B1CYP11B2IDO1GAAPKM | |
| SCHEMBL6774868 | 0.76 | CYP11B1 (0.54) | CYP11B1CYP11B2HSP90AA1HSP90AB1IDO1 | |
| SCHEMBL15458790 | 0.76 | CYP11B1 (0.57) | CYP11B1CYP11B2HSP90AA1HSP90AB1IDO1 | |
| SCHEMBL27316522 | 0.74 | CYP11B1 (0.60) | CYP11B1CYP11B2HSP90AA1HSP90AB1IDO1 | |
| SCHEMBL10790711 | 0.73 | CYP11B1 (0.54) | CYP11B1CYP11B2HSP90AA1HSP90AB1IDO1 | |
| SCHEMBL9092959 | 0.73 | CYP11B1 (0.52) | CYP11B1CYP11B2HSP90AA1HSP90AB1IDO1 | |
| SCHEMBL27306308 | 0.73 | CYP11B1 (0.52) | CYP11B1CYP11B2HSP90AA1HSP90AB1IDO1 | |
| SCHEMBL27388454 | 0.72 | CYP11B1 (0.50) | CYP11B1CYP11B2HSP90AA1HSP90AB1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091200-B2 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists | SYNTEX U.S.A. LLC (US) | 2006-08-15 | — | — | US | disclosed |
| US-6900220-B2 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists | SYNTEX (U.S.A.) LLC (US) | 2005-05-31 | — | — | US | disclosed |
| US-20050107365-A1 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists | BECKER CYRUS K (US) | 2005-05-19 | — | — | US | disclosed |
| US-20030069230-A1 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists | SYNTEX (U.S.A.) LLC | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069230-A1 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists | ADRB1, ADRB2, ADRA2B | CYP11B1 81/4885CYP11B2 89/4885HSP90AA1 2480/4885 |
| US-20050107365-A1 | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists | ADRB1, ADRB2, ADRA2B | CYP11B1 82/4885CYP11B2 86/4885HSP90AA1 2533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.