Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.50 |
| ▸ | MMP1 | P03956 | 3/20 | 0.49 |
| ▸ | MMP12 | P39900 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 7/20 | 0.48 |
| ▸ | MMP9 | P14780 | 5/20 | 0.48 |
| ▸ | MMP3 | P08254 | 3/20 | 0.48 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | MMP7 | P09237 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899488 | 0.91 | KAT6A (0.49) | MMP1GAAMMP2MMP9MMP13 | |
| SCHEMBL5899419 | 0.88 | ALDH1A1 (0.49) | MMP1GAAMMP2MMP9MMP13 | |
| SCHEMBL5899418 | 0.87 | PFKFB3 (0.54) | MEN1MAPTKMT2AKAT6A | |
| SCHEMBL5899422 | 0.87 | FLT1 (0.57) | MMP1MMP12GAAMMP2MMP9 | |
| SCHEMBL5899495 | 0.87 | ALDH1A1 (0.50) | MEN1MAPTRECQLKMT2AUQCRB | |
| SCHEMBL5899463 | 0.87 | ITGA1 (0.49) | MMP1MMP2MMP9MMP3MMP13 | |
| SCHEMBL14675960 | 0.86 | ADAMTS4 (0.54) | ADAMTS4MMP1MMP12GAAMMP2 | |
| SCHEMBL5899456 | 0.84 | MMP2 (0.59) | ADAMTS4MMP1MMP2MMP9MMP3 | |
| SCHEMBL5899452 | 0.82 | KAT6A (0.48) | POLBUSP30MEN1MAPTHTT | |
| SCHEMBL5899486 | 0.81 | KAT6A (0.57) | GAAKAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | WYETH | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | ADAMTS4 397/4885MMP1 369/4885MMP12 322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.