Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.54 |
| ▸ | KAT6A | Q92794 | 10/20 | 0.50 |
| ▸ | ACLY | P53396 | 4/20 | 0.47 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.47 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899417 | 0.87 | ADAMTS4 (0.50) | KAT6AMEN1MAPTKMT2A | |
| SCHEMBL5899488 | 0.87 | KAT6A (0.49) | KAT6AMEN1KMT2A | |
| SCHEMBL5899486 | 0.81 | KAT6A (0.57) | KAT6ALMNASMN1; SMN2 | |
| SCHEMBL28783847 | 0.81 | MAPT (0.67) | PFKFB3KAT6ALARS1PTGES2FLT1 | |
| SCHEMBL5899671 | 0.80 | ACLY (0.44) | KAT6AACLYMEN1LMNAMAPT | |
| SCHEMBL5899700 | 0.78 | HTT (0.44) | MEN1NPC1LMNAMAPTRAB9A | |
| SCHEMBL5899419 | 0.78 | ALDH1A1 (0.49) | KDM4ELMNAHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL1069771 | 0.77 | PTGES2 (0.50) | PFKFB3KAT6AACLYLARS1PTGES2 | |
| SCHEMBL5899422 | 0.77 | FLT1 (0.57) | FLT1FLT4KDRMEN1LMNA | |
| SCHEMBL5899463 | 0.77 | ITGA1 (0.49) | KAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | WYETH | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | PFKFB3 2979/4885KAT6A 2440/4885ACLY 1905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.