Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.51 |
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899440 | 0.89 | TAS2R14 (0.63) | HSD11B1TAS2R14MEN1KMT2AALDH1A1 | |
| SCHEMBL5899445 | 0.82 | TAS2R14 (0.66) | TAS2R14MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL5899607 | 0.82 | HSD11B1 (0.57) | HSD11B1MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL5899442 | 0.79 | PTPN1 (0.57) | HSD11B1TAS2R14MEN1KMT2AKEAP1 | |
| SCHEMBL5899551 | 0.76 | TAS2R14 (0.56) | TAS2R14MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11802279 | 0.76 | MAPK1 (0.71) | MAPK1ALDH1A1KEAP1NFE2L2MMP1 | |
| SCHEMBL11324196 | 0.75 | MMP1 (0.52) | MEN1KMT2AMAPK1ALDH1A1KDM4E | |
| SCHEMBL27614871 | 0.75 | ALDH1A1 (0.50) | HSD11B1MEN1KMT2AMAPK1ALDH1A1 | |
| SCHEMBL14145796 | 0.75 | RECQL (0.60) | HSD11B1TAS2R14MEN1KMT2AALDH1A1 | |
| SCHEMBL6347967 | 0.74 | MMP9 (0.56) | HSD11B1MMP1MMP2MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | WYETH | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885TAS2R14 4454/4885MEN1 1269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.