Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | NAT1 | P18440 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5899419 | 0.87 | ALDH1A1 (0.49) | LMNAALDH1A1TP53TDP1KMT2A | |
| SCHEMBL5899488 | 0.86 | KAT6A (0.49) | KAT6ACES1ALDH1A1MEN1KMT2A | |
| SCHEMBL14676471 | 0.81 | SLC1A3 (0.46) | ACLYLMNATHRBSLC1A3SLC1A2 | |
| SCHEMBL5899700 | 0.81 | HTT (0.44) | LMNAALDH1A1TP53MEN1KMT2A | |
| SCHEMBL5899417 | 0.81 | ADAMTS4 (0.50) | KAT6AMEN1KMT2AMAPT | |
| SCHEMBL5899486 | 0.80 | KAT6A (0.57) | KAT6ALMNASLC1A3SLC1A2SLC1A1 | |
| SCHEMBL5899418 | 0.80 | PFKFB3 (0.54) | ACLYKAT6ALMNAMEN1KMT2A | |
| SCHEMBL5899495 | 0.79 | ALDH1A1 (0.50) | LMNASLC1A2ALDH1A1MEN1KMT2A | |
| SCHEMBL5899422 | 0.79 | FLT1 (0.57) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL5899463 | 0.79 | ITGA1 (0.49) | KAT6AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | WYETH | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025445-A1 | 11-Beta HSD1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | ACLY 1905/4885KAT6A 2440/4885LMNA 3336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.