Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butane SCHEMBL3151311 | 0.96 | LMNA (0.52) | LMNAALDH1A1HSD17B10CHRNB2CHRNA4 | |
| Acetone SCHEMBL590699 | 0.85 | LMNA (0.71) | LMNAALDH1A1HSD17B10THRB | |
| Acetic Acid SCHEMBL23907968 | 0.82 | LMNA (0.67) | LMNAALDH1A1HSD17B10THRB | |
| Butanedione SCHEMBL4368674 | 0.82 | LMNA (0.67) | LMNAALDH1A1HSD17B10THRB | |
| Acetic Acid SCHEMBL222953 | 0.82 | LMNA (0.67) | LMNAALDH1A1HSD17B10THRB | |
| SCHEMBL6848043 | 0.80 | LMNA (0.50) | LMNAALDH1A1HSD17B10 | |
| Diamide SCHEMBL3943566 | 0.80 | ALDH1A1 (0.54) | LMNAALDH1A1HSD17B10CHRNB2CHRNA4 | |
| Butane SCHEMBL3150354 | 0.80 | LMNA (0.50) | LMNAALDH1A1CHRNB2CHRNA4CHRNB4 | |
| Butanone SCHEMBL3163812 | 0.80 | LMNA (0.63) | LMNAALDH1A1HSD17B10THRB | |
| Acetic Acid SCHEMBL8529879 | 0.80 | LMNA (0.63) | LMNAALDH1A1HSD17B10THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060058329-A1 | Pyrazole inhibitors of the transforming growth factor | SMITHKLINE BEECHAM CORPORATION | 2006-03-16 | — | — | US | disclosed |
| US-20050245520-A1 | 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors | DODIC NERINA | 2005-11-03 | — | — | US | disclosed |
| EP-1554268-A1 | PYRAZOLE INHIBITORS OF THE TRANSFORMING GROWTH FACTOR | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004016606-A1 | PYRAZOLE INHIBITORS OF THE TRANSFORMING GROWTH FACTOR | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-26 | — | — | WO | disclosed |
| US-4602013-A | 3,5-DIAMINO-6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZINE, ANTICONVULSANTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245520-A1 | 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors | SMAD2, SMAD3, ALK | LMNA 972/4885ALDH1A1 3370/4885HSD17B10 3888/4885 |
| US-20060058329-A1 | Pyrazole inhibitors of the transforming growth factor | SMAD3, SMAD2, TGFBR1 | LMNA 1917/4885ALDH1A1 3456/4885HSD17B10 4019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.